{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:53:56Z","timestamp":1777712036970,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Science Foundation of Hunan Province","award":["2015JJ4053"],"award-info":[{"award-number":["2015JJ4053"]}]},{"name":"Science and technology million project of Inner Mongolia medical university","award":["YKD2017KJBW016"],"award-info":[{"award-number":["YKD2017KJBW016"]}]},{"name":"Hunan health and family planning commission research project","award":["B2016-126,2015-40"],"award-info":[{"award-number":["B2016-126,2015-40"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in the treatment of various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role of the microRNA-mediated regulation of angiogenesis in ischemic tissues, and a series of microRNAs associated with angiogenesis have been successively identified. In this study, we found that miR-195 expression was significantly upregulated and the microvessel density (MVD) was increased in granulation tissue collected 7 days after NPWT compared with those in the pre-NPWT tissue. Moreover, the expression of NLRX1, the potential target gene of miR-195, was down-regulated in post-NPWT compared with that in pre-NPWT tissue. Significant negative correlations were detected between miR-195 and NLRX1 expression levels ( r = \u2212.856, P &lt; .001) and between NLRX1 expression and MVD ( r = \u2212.618, P &lt; .05), whereas miR-195 expression was positively correlated with MVD in the granulation tissue ( r = .630, P &lt; .05). In summary, NPWT may suppress NLRX1 expression through the upregulation of miR-195 expression, thus efficaciously promoting angiogenesis in the granulation tissue to enhance wound healing.<\/jats:p>","DOI":"10.1177\/1534734618794856","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T07:41:47Z","timestamp":1535096507000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-0469","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Central South University Third Xiangya Hospital, Changsha, Hunan Province, China"},{"name":"Inner Mongolia Medical University, Hohhot, Inner Mongolia 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