{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:06:59Z","timestamp":1789348019011,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Masers Electronic Pvt. Ltd."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    The diabetic foot ulcer (DFU) healing rates remain dismally low. Therefore, many adjunctive therapies have been evaluated including ultrasound therapy. The prior studies with noncontact, low-frequency ultrasound were retrospective, single arm, unblinded, or with historical controls. The aim of the present study was to compare the efficacy of noncontact, low-frequency airborne ultrasound (Glybetac) therapy with sham therapy added to standard treatment in patients with neuropathic, clinically infected, or noninfected DFU (wound size &gt;2 cm\n                    <jats:sup>2<\/jats:sup>\n                    ), Wagner grades 2 and 3. Patients received ultrasound or sham therapy for 28 days dosed daily for first 6 days followed by twice a week for next 3 weeks along with standard of care. The primary outcome was percentage of patients with at least &gt;50% decrease in wound area at 4 week of intervention. Fifty-eight patients completed the study protocol. The duration of wound was 15.8 \u00b1 11.2 weeks and 12.1 \u00b1 10.9 weeks and wound area of 11.3 \u00b1 8.2 cm\n                    <jats:sup>2<\/jats:sup>\n                    and 14.8 \u00b1 13.8 cm\n                    <jats:sup>2<\/jats:sup>\n                    ( P = .507) in the ultrasound and sham groups, respectively. A &gt;50% reduction in wound area was observed in 97.1% and 73.1% subjects ( P = .042) in ultrasound and sham groups, respectively. Wound contraction was faster in the first 2 weeks with ultrasound therapy, 5.3 cm\n                    <jats:sup>2<\/jats:sup>\n                    , compared with 3.0 cm\n                    <jats:sup>2<\/jats:sup>\n                    ( P = .025) with sham treatment. Overall, wound area reduction of 69.4 \u00b1 23.2% and 59.6 \u00b1 24.9% ( P = .126) was observed at 4 weeks in the ultrasound and sham groups, respectively. We conclude that the airborne low-frequency ultrasound therapy improves and hastens the healing of chronic neuropathic DFU when combined with standard wound care.\n                  <\/jats:p>","DOI":"10.1177\/1534734619832738","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T01:21:36Z","timestamp":1551835296000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy and Safety of Low-Frequency, Noncontact Airborne Ultrasound Therapy (Glybetac) For Neuropathic Diabetic Foot Ulcers: A Randomized, Double-Blind, Sham-Control Study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-3102","authenticated-orcid":false,"given":"Ashu","family":"Rastogi","sequence":"first","affiliation":[{"name":"Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Maser India, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"bibr1-1534734619832738","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.1.24"},{"key":"bibr2-1534734619832738","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"bibr3-1534734619832738","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5005\/jp-journals-10040-1052","volume":"3","author":"Rastogi A","year":"2016","journal-title":"J Foot Ankle Surg 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