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A round full thickness skin defect with a diameter of 7 mm was made in the mice model. The experimental mice were divided into 4 groups (n = 12 each): group A (control group), group B (scaffold group), group C (ADSCs-scaffold group), and group D (Bcl-2-ADSCs-scaffold group). On days 3, 7, 10, and 14 after surgery, characteristics of wound healing was observed, and wound tissues were sampled for histology characteristics via hematoxylin-eosin staining and immunohistochemical staining. Compared with other groups, the wound healing rate was significantly higher in group D a week after operation ( P &lt; .05). On the seventh day postoperation, group D exhibited higher blood vessel in the wounds granulation tissue than other groups according to results of hematoxylin-eosin staining and immunohistochemistry. In conclusion, these findings demonstrated that collagen scaffold with Bcl-2 modified ADSCs may effectively improve the wound healing process in diabetic mice.<\/jats:p>","DOI":"10.1177\/1534734619880055","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T05:35:27Z","timestamp":1572845727000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Collagen Scaffold With Bcl-2-Modified Adipose-Derived Stem Cells on Diabetic Mice Wound Healing"],"prefix":"10.1177","volume":"19","author":[{"given":"Sheng","family":"Ding","sequence":"first","affiliation":[{"name":"Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China"},{"name":"Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, 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