{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:06Z","timestamp":1787019246681,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    Diabetic foot ulcers (DFUs) are considered one of the most aggressive and expensive complications of diabetes. Low-level laser therapy (LLLT) has been highlighted as a potential modality of treatment to accelerate the healing of ulcers. This systematic review and meta-analysis aimed to investigate the efficacy of LLLT in the treatment of DFU and identify the LLLT application parameters recommended for the treatment of DFU over the past 10 years. A systematic search was conducted in PubMed, BVS, PEDro, Scopus, Web of Science, and CINAHL up to March 31, 2019. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, randomized controlled trials (RCTs) that assessed the effect of LLLT on the treatment of DFU were included. Thirteen RCTs with a total of 361 participants were included in this review. Three RCTs reported a reduction in the percentage size of the ulcers and were included in the meta-analysis. The meta-analysis of the percentage size difference demonstrated a significant reduction in ulcer size in the LLLT group compared with controls (22.96 [95% confidence interval = 18.22-27.69; z = 9.51, P &lt; .0001]). Treatment with 632.8 to 685 nm, 50 mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 3 to 6 J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , and irradiation for 30 to 80 seconds, 3 times weekly for a month is of benefit to patients with DFU. LLLT is effective and safe for the treatment of DFU. Additionally, well-designed, high-quality studies are needed to allow its ideal parameterization for clinical practice.\n                  <\/jats:p>","DOI":"10.1177\/1534734620914439","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T06:03:59Z","timestamp":1589263439000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["A Systematic Review and Meta-Analysis of the Effects of Low-Level Laser Therapy in the Treatment of Diabetic Foot Ulcers"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-7393","authenticated-orcid":false,"given":"Cristiana Maria dos","family":"Santos","sequence":"first","affiliation":[{"name":"Federal University of Piaui, Piaui, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Barbosa da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Federal University of Piaui, Piaui, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad Ahmad","family":"Hazime","sequence":"additional","affiliation":[{"name":"Federal University of Piaui, Piaui, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Saura","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Federal University of Piaui, Piaui, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"bibr1-1534734620914439","doi-asserted-by":"publisher","DOI":"10.4103\/2468-8827.184853"},{"key":"bibr2-1534734620914439","doi-asserted-by":"publisher","DOI":"10.13181\/mji.v26i1.1401"},{"key":"bibr3-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"bibr4-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7132861"},{"key":"bibr5-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"bibr6-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979152"},{"key":"bibr7-1534734620914439","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v10.i3.200"},{"key":"bibr8-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"bibr9-1534734620914439","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010089"},{"key":"bibr10-1534734620914439","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.6.292"},{"key":"bibr11-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12816"},{"key":"bibr12-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-015-0687-5"},{"key":"bibr13-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"bibr14-1534734620914439","doi-asserted-by":"crossref","unstructured":"Schaper NC, van Netten JJ, Apelqvist J, et al; International Working Group on the Diabetic Foot (IWGDF). IWGDF practical guidelines on the prevention and management of diabetic foot disease. https:\/\/iwgdfguidelines.org\/wp-content\/uploads\/2019\/05\/01-IWGDF-practical-guidelines-2019.pdf. Accessed October 10, 2019.","DOI":"10.1002\/dmrr.3266"},{"key":"bibr15-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912014000200010"},{"key":"bibr16-1534734620914439","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2553-2"},{"key":"bibr17-1534734620914439","doi-asserted-by":"crossref","unstructured":"Feitosa MCP, de Carvalho AFM, Feitosa VC, et al. Pain and quality of life of diabetic patients with ulcers, before and after treatment with low intensity laser therapy and\n                      Hellantus annus\n                      oil [in Portuguese]. Mundo da sa\u00fade. 2017;41:18-29. http:\/\/bvsms.saude.gov.br\/bvs\/periodicos\/mundo_saude_artigos\/Dor_qualidade_vida.pdf. 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The effect of Gallium-Arsenide laser (904 nm) on wound healing and alteration of ankle-branch index in diabetic foot ulcer [in Persian]. Zanjan Univ Med Sci Health Services. 2016;24:20-31. https:\/\/www.sid.ir\/fa\/Journal\/ViewPaper.aspx?ID=256469. 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