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However, there is no study investigating how microvascular control mechanism respond to different walking intensities in people with and without diabetes. The purpose of this study was to assess microvascular control mechanism of the plantar foot in response to various walking speeds and durations in 12 healthy people using spectral analysis of skin blood flow (SBF) oscillations. A 3\u00d72 factorial design, including 3 speeds (3, 6, and 9 km\/h) and 2 durations (10 and 20 minutes), was used in this study. Plantar SBF was measured using laser Doppler flowmetry over the first metatarsal head. Borg Rating of Perceived Exertion (RPE) scale and heart rate maximum were used to assess the walking intensity. Wavelet analysis was used to quantify regulations of metabolic (0.0095-0.02 Hz), neurogenic (0.02-0.05 Hz), myogenic (0.05-0.15 Hz), respiratory (0.15-0.4 Hz), and cardiac (0.4-2 Hz) controls. For 10-minute walking, walking at 9 km\/h significantly increased the ratio of wavelet amplitudes of metabolic, neurogenic, myogenic, respiratory, and cardiac mechanisms compared with 3 km\/h ( P &lt; .05). For 20-minute walking, walking at 6 km\/h significantly increased the ratio of wavelet amplitudes of metabolic, myogenic, respiratory, and cardiac compared with 3 km\/h ( P &lt; .05). RPE showed a significant interaction between the speed and duration factors ( P &lt; .01). This is the first study demonstrating that different walking speeds and durations caused different plantar microvascular regulations.<\/jats:p>","DOI":"10.1177\/1534734620915360","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T02:08:31Z","timestamp":1587694111000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Microvascular Control Mechanism of the Plantar Foot in Response to Different Walking Speeds and Durations: Implication for the Prevention of Foot Ulcers"],"prefix":"10.1177","volume":"20","author":[{"given":"Fu-Lien","family":"Wu","sequence":"first","affiliation":[{"name":"University of Illinois at Urbana-Champaign, Champaign, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy T.","family":"Wang","sequence":"additional","affiliation":[{"name":"National Yang-Ming University, 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