{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:04Z","timestamp":1777712344452,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Nicolau syndrome (NS) is a rare cutaneous drug reaction in response to injections administered via any route. Based on the available studies in the medical literature, NS presents as skin and subcutaneous fat necrosis, and typically, it does not cause severe complications such as acute limb ischemia or death. In this study, we report the case of a 6-year-old boy who received an intramuscular injection of benzathine penicillin G for the treatment of bacterial pharyngitis, and subsequently developed a severe case of NS, which eventually led to below-knee amputation of the right lower limb. Although a few approaches have been suggested for the management of NS, they might not be effective under certain circumstances. Early detection, close monitoring, and consistent interventions, such as surgical fasciotomy and debridement procedures, might be necessary in severe cases of NS.<\/jats:p>","DOI":"10.1177\/1534734620948768","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:34:13Z","timestamp":1597714453000},"page":"113-116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Extensive Deep Tissue Involvement in Nicolau Syndrome and Below-Knee Amputation: A Case Report and Literature Review"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-6353","authenticated-orcid":false,"given":"Ramin","family":"Zargarbashi","sequence":"first","affiliation":[{"name":"Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Panjavi","sequence":"additional","affiliation":[{"name":"Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-5878","authenticated-orcid":false,"given":"Mahsa","family":"Keshavarz-Fathi","sequence":"additional","affiliation":[{"name":"Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Cancer Immunology Project, Universal Scientific Education and Research Network, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"bibr1-1534734620948768","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58523"},{"key":"bibr2-1534734620948768","first-page":"577","volume":"39","author":"Noaparast M","year":"2014","journal-title":"Iran J Med Sci"},{"key":"bibr3-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2018.04.012"},{"key":"bibr4-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15322"},{"key":"bibr5-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00137-4"},{"key":"bibr6-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1024\/1661-8157.95.39.1499"},{"key":"bibr7-1534734620948768","first-page":"87","volume":"4","author":"Enshaei A","year":"2016","journal-title":"Arch Bone Joint Surg"},{"key":"bibr8-1534734620948768","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.43523"},{"key":"bibr9-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.11.022"},{"key":"bibr10-1534734620948768","first-page":"860","volume":"74","author":"Hamilton B","year":"2008","journal-title":"Acta Orthop Belg"},{"key":"bibr11-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0964-6"},{"key":"bibr12-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.046"},{"key":"bibr13-1534734620948768","unstructured":"Nicolau S. Dermite livedoide et gangr\u00e9neuse de la fesse, cons\u00e9cutive aux injections intra-musculaires, dans la syphilis. A propos dun cas dembolie art\u00e9rielle bismuthique. 1925:321-339. https:\/\/www.semanticscholar.org\/paper\/Dermite-liv%C3%A9do%C3%AFde-et-gangr%C3%A9neuse-de-la-fesse%2C-aux-A-Nicolau\/5c3f0995dbe582df582115e8308095e407a8a3e0"},{"key":"bibr14-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00320.x"},{"key":"bibr15-1534734620948768","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.4.501"},{"key":"bibr16-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02674.x"},{"key":"bibr17-1534734620948768","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_53_18"},{"key":"bibr18-1534734620948768","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-404"},{"key":"bibr19-1534734620948768","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11705.1"},{"key":"bibr20-1534734620948768","doi-asserted-by":"publisher","DOI":"10.4103\/2319-7250.139510"},{"key":"bibr21-1534734620948768","first-page":"174","volume":"113","author":"Richter K","year":"2013","journal-title":"J Am Osteopath Assoc"},{"key":"bibr22-1534734620948768","first-page":"301","volume":"23","author":"Sumpio B","year":"2011","journal-title":"Wounds"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734620948768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534734620948768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734620948768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:04Z","timestamp":1777457104000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734620948768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/1534734620948768"],"URL":"https:\/\/doi.org\/10.1177\/1534734620948768","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]}}}