{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:58:27Z","timestamp":1777712307656,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Laboratoires Urgo Medical"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    Regarding the positive clinical outcomes of sucrose octasulfate impregnated dressing documented in neuroischemic diabetic foot ulcers (DFUs), we aimed to evaluate the microcirculatory status in patients with neuroischemic DFU through the use of sucrose octasulfate dressing. Eleven patients with neuroischemic DFU were included in a prospective pilot study between July 2019 and March 2020. We evaluated the effect in transcutaneous oxygen pressure (TcPO\n                    <jats:sub>2<\/jats:sub>\n                    ; mm Hg) values within the use of a sucrose octasulfate dressing in the course of the healing process of neuroischemic DFUs (UrgoStart Contact, Laboratoires Urgo Medical). TcPO\n                    <jats:sub>2<\/jats:sub>\n                    values were assessed at day 0 and monthly until wound healing was achieved. Additionally, wound healing process was evaluated using the Wollina score system and wound area surface, at day 0 and monthly until 20 weeks of follow-up or wound healing first occurred. TcPO\n                    <jats:sub>2<\/jats:sub>\n                    values showed a significant increase between day 0 (29.45 \u00b1 7.38 mm Hg) and wound closure (46.54 \u00b1 11.45 mm Hg, P = .016), after dressing application. Wollina wound scores showed a significant improvement (4.2 \u00b1 1.7 at day 0 to 5.4 \u00b1 1.3 at the end of the study; P = .004). Median wound area at day 0 was 1.30 cm\n                    <jats:sup>2<\/jats:sup>\n                    , interquartile range [1.60-1] cm\n                    <jats:sup>2<\/jats:sup>\n                    , and 0.5 cm\n                    <jats:sup>2<\/jats:sup>\n                    at week 4, interquartile range [1.1-0.1], P &lt; .001. Median healing time was 8 weeks, interquartile range [8-5]. Treating a neuroischemic DFU with a sucrose octasulfate dressing in the standard of care showed an increase in skin oxygen pressure.\n                  <\/jats:p>","DOI":"10.1177\/1534734620952244","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T07:14:16Z","timestamp":1598598856000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Increasing Transcutaneous Oxygen Pressure in Patients With Neuroischemic Diabetic Foot Ulcers Treated With a Sucrose Octasulfate Dressing: A Pilot Study"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"L\u00e1zaro-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Diabetic Foot Unit, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-7378","authenticated-orcid":false,"given":"Marta","family":"Garc\u00eda-Madrid","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Garc\u00eda-Alamino","sequence":"additional","affiliation":[{"name":"Medical Director, Laboratoires URGO, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Bohbot","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Director, Laboratoires URGO, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Garc\u00eda-Klepzig","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Garc\u00eda-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"bibr1-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"bibr2-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734611400257"},{"key":"bibr3-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1856-6"},{"key":"bibr4-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0491-1"},{"key":"bibr5-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/193229681100500636"},{"key":"bibr6-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3244"},{"key":"bibr7-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734606292037"},{"key":"bibr8-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/153473460200100303"},{"key":"bibr9-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734618813229"},{"key":"bibr10-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1076029606290133"},{"key":"bibr11-1534734620952244","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc18101"},{"key":"bibr12-1534734620952244","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.4.580"},{"key":"bibr13-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.12.006"},{"key":"bibr14-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3283"},{"key":"bibr15-1534734620952244","unstructured":"National Institute for Health and Care Excellence. UrgoStart for treating leg ulcers and diabetic foot ulcers. Medical technologies guidance [MTG42]. Published January 31, 2019. Accessed August 8, 2020. https:\/\/www.nice.org.uk\/guidance\/mtg42"},{"key":"bibr16-1534734620952244","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/jowc.2015.24.Sup5.S1","volume":"24","author":"White R","year":"2015","journal-title":"J Wound Care"},{"key":"bibr17-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(17)30438-2"},{"key":"bibr18-1534734620952244","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.6.358"},{"key":"bibr19-1534734620952244","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"bibr20-1534734620952244","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.855"},{"key":"bibr21-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3266"},{"key":"bibr22-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13263"},{"key":"bibr23-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3276"},{"key":"bibr24-1534734620952244","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.11.790"},{"key":"bibr25-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-016-1434-y"},{"key":"bibr26-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734609346839"},{"key":"bibr27-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613502043"},{"key":"bibr28-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/1534734605283001"},{"key":"bibr29-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3274"},{"key":"bibr30-1534734620952244","doi-asserted-by":"publisher","DOI":"10.1177\/0003319719866958"},{"key":"bibr31-1534734620952244","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.12.808"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734620952244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534734620952244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534734620952244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:04:57Z","timestamp":1777457097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534734620952244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/1534734620952244"],"URL":"https:\/\/doi.org\/10.1177\/1534734620952244","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]}}}