{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:47:56Z","timestamp":1783381676060,"version":"3.54.6"},"reference-count":104,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Exercise therapy is a core element in the treatment of diabetes, but the benefits and harms for patients with a diabetic foot ulcer (DFU) are unknown. We therefore aimed to systematically review the benefits on health-related quality of life (HRQoL) and harms of exercise therapy for patients with DFU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched 6 major databases. We performed citation and reference searches of included studies and contacted authors of ongoing trials. We included randomized controlled trials (RCTs) to assess potential benefits on HRQoL and harms of exercise therapy. Observational studies were included to identify potential harms of exercise therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 10 published publications of 9 trials and results from 2 unpublished trials including a total of 281 individuals with DFUs receiving various forms of exercise therapy. Due to lack of HRQoL measurements and high heterogeneity, it was not possible to perform meta-analyses. Results on HRQoL was present in one unpublished study. Harms reported ranged from musculoskeletal problems, increased wound size, to amputation; however, no safe conclusions could be drawn from the available data due to high heterogeneity and risk of bias in the trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\/Interpretation<\/jats:title>\n                    <jats:p>Protective strategies are often preferred over therapeutic exercise that might have unforeseen consequences for patients over time. Based on the current literature, no evidence-based recommendations can be provided on the benefits and harms of exercise therapy for patients with DFUs. Well-conducted RCTs are needed to guide rehabilitation including detailed description of adverse events and an exercise program in a semisupervised or fully supervised setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1534734620954066","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:45:21Z","timestamp":1600076721000},"page":"219-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Benefits and Harms of Exercise Therapy for Patients With Diabetic Foot Ulcers: A Systematic Review"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-5982","authenticated-orcid":false,"given":"Thomas Vedste","family":"Aagaard","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Holbaek Hospital, Holbaek, Denmark"},{"name":"Department of Orthopaedic Surgery, Holbaek Hospital, Holbaek, Denmark"},{"name":"Department of Orthopaedic Surgery, Zealand University Hospital, Koege, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Moeini","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Zealand University Hospital, Koege, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-7059","authenticated-orcid":false,"given":"S\u00f8ren T.","family":"Skou","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Slagelse, Denmark"},{"name":"Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla Riis","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Holbaek Hospital, Holbaek, Denmark"},{"name":"The Danish Knowledge Centre for Rehabilitation and Palliative Care. University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Brorson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Zealand University Hospital, Koege, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"bibr1-1534734620954066","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.491"},{"key":"bibr2-1534734620954066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01640.x"},{"key":"bibr3-1534734620954066","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"bibr4-1534734620954066","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1226-2"},{"key":"bibr5-1534734620954066","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00422.x"},{"key":"bibr6-1534734620954066","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0306"},{"key":"bibr7-1534734620954066","first-page":"444","volume":"56","author":"Gul A","year":"2006","journal-title":"J Pak Med Assoc"},{"key":"bibr8-1534734620954066","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.295988"},{"key":"bibr9-1534734620954066","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2235"},{"key":"bibr10-1534734620954066","unstructured":"International Working Group on the Diabetic Foot. 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