{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:13:53Z","timestamp":1783998833045,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"HARTMANN GROUP"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>The aim of the research is to assess the benefit\u2013harm of superabsorbent polymers wound dressings based on polyacrylate polymers (SAPs) compared with standard of care (SoC) dressing mix for patients with moderate-to-highly exuding hard-to-heal leg ulcers. The SoC dressings mix was composed of other superabsorbents in 29% of cases, antimicrobials 26%, foams 20%, alginates 5%, and other dressings 19% weighted according to their frequency. We have used the decision-analytic modeling method, Markov process, as an adequate analytical solution for medical prognosis. We have combined the systematic literature search to identify the most relevant inputs for the analysis, with available patient-level clinical data concerning benefits of superabsorbent to generate a robust prediction of patient-relevant outcomes, including healing rates and health-related quality of life. Besides, we have qualitatively described adverse events associated with those treatments. Our research indicates that SAPs when compared with SoC dressing mix in a patient with moderate-to-highly excluding leg ulcers are leading to an improved healing rate with an absolute risk difference of 2.20% in 6 months and a relative risk of 1.07 in favor of SAP dressings. The attributable fraction among those exposed to SAP dressings of 6.6%, meaning that 6.6% of the healed ulcers could be attributed to having had the SAP dressing treatment instead of the SoC dressing treatment. Besides, SAP dressings lead to improved quality of life measured as incremental quality-adjusted life weeks (QALWs) of 0.13 QALWs.<\/jats:p>","DOI":"10.1177\/15347346211009399","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T12:08:40Z","timestamp":1620043720000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Superabsorbent Wound Dressing for Management of Patients With Moderate-to-Highly Exuding Chronic Leg Ulcers: An Early Stage Model-Based Benefit\u2013Harm Assessment"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-1267","authenticated-orcid":false,"given":"Vladica M.","family":"Velickovic","sequence":"first","affiliation":[{"name":"HARTMANN GROUP, Heidenheim, Germany"},{"name":"Institute of Public Health, Medical Decision Making and HTA, UMIT, Hall i.T., Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Lembelembe","sequence":"additional","affiliation":[{"name":"Clinique des Augustines, Malestroit, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cegri","sequence":"additional","affiliation":[{"name":"Primary Care Center (CAP), Sant Mart\u00ed de Proven\u00e7als, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Binic","sequence":"additional","affiliation":[{"name":"University of Nis, Nis, Serbia"},{"name":"Clinical Centre of Nis (University Hospital), Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-4042","authenticated-orcid":false,"given":"Amr B.","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-3025","authenticated-orcid":false,"given":"Sun","family":"Sun","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandt","family":"Niki","sequence":"additional","affiliation":[{"name":"HARTMANN GROUP, Heidenheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stevens","family":"Dawn","sequence":"additional","affiliation":[{"name":"PAUL HARTMANN Ltd, Heywood, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Rippon","sequence":"additional","affiliation":[{"name":"Huddersfield University, Queensgate, Huddersfield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon K.","family":"Abreha","sequence":"additional","affiliation":[{"name":"University of Insubria, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sturges","sequence":"additional","affiliation":[{"name":"Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"bibr1-15347346211009399","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"bibr2-15347346211009399","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"bibr3-15347346211009399","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7140.1310"},{"key":"bibr4-15347346211009399","unstructured":"Harding K, Carville k, Chadwick P, et al. 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