{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:26:04Z","timestamp":1785713164104,"version":"3.56.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    Impaired wound healing is a major concern in diabetic patients due to unregulated chronic hyperglycemia which further may lead to ulcer, gangrene, and its complications. The present study unveils the accelerative effect of aqueous Anthocephalus cadamba leaf extract on wound healing in diabetic rats. Diabetes was induced in 30 Sprague Dawley female rats by using streptozotocin (except control group I) at the dose of 60\u2005mg\/kg intraperitoneally. Diabetic rats were randomized in 3 groups viz. diabetic control group (II), diabetes\u2009+\u2009Kadam plant leaf extract group (III), and diabetes\u2009+\u20095% povidone\u2013iodine solution group (IV). Surgically sterile wound of 1.77\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    was created on the dorsal area of anaesthetized rats. The experimental parameters were assessed by hematobiochemical, histopathological, and western blot techniques. The A cadamba extract treatment group (III) (D\u2009+\u2009KPLE) showed a significant increase in the percentage of wound closure (82%) at day 21 as compared to the diabetic control group (42%), nondiabetic control group (I) (49%), and povidone\u2013iodine treatment group (75%) group (IV). The findings of the present study suggest that the (D\u2009+\u2009KPLE) group (III) exhibited marked epithelial regeneration, neovascularization, collagen deposition, and fibroblast proliferation along with higher expression of vascular endothelial growth factor as compared to the diabetic control group (II), which was confirmed by histopathological examination and western blot analysis. The present study suggests that the topical application of aqueous A cadamba leaf extract exhibits accelerative wound-healing properties in diabetic rats.\n                  <\/jats:p>","DOI":"10.1177\/15347346211018330","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T09:39:18Z","timestamp":1620985158000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Accelerative Wound-Healing Effect of Aqueous\n                    <i>Anthocephalus Cadamba<\/i>\n                    Leaf Extract in a Diabetic Rat Model"],"prefix":"10.1177","volume":"22","author":[{"given":"Shoket","family":"Ali","sequence":"first","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmeen","family":"Ishteyaque","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foziya","family":"Khan","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragati","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Soni","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-3860","authenticated-orcid":false,"given":"Madhav N.","family":"Mugale","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"bibr1-15347346211018330","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup10.S26"},{"key":"bibr2-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/124352"},{"issue":"1","key":"bibr3-15347346211018330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-018-2420-5","volume":"19","author":"Tan WS","year":"2019","journal-title":"BMC Compl Alternative Med"},{"issue":"1","key":"bibr4-15347346211018330","volume":"13","author":"Harsha L","year":"2020","journal-title":"Drug Invent Today"},{"key":"bibr5-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01922"},{"key":"bibr6-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21385"},{"key":"bibr7-15347346211018330","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i4.67"},{"key":"bibr8-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/747584"},{"key":"bibr9-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.02.014"},{"key":"bibr10-15347346211018330","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v4i4.31241"},{"key":"bibr11-15347346211018330","doi-asserted-by":"crossref","first-page":"208","DOI":"10.7897\/2277-4572.075109","volume":"7","author":"Ogale S","year":"2018","journal-title":"J Pharm Innov"},{"key":"bibr12-15347346211018330","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.15514"},{"key":"bibr13-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.08.009"},{"key":"bibr14-15347346211018330","volume":"30","author":"Belachew TF","year":"2020","journal-title":"Evid-Based Complementary Altern Med"},{"issue":"1","key":"bibr15-15347346211018330","first-page":"51","volume":"37","author":"Rabenberg VS","year":"2002","journal-title":"J Athl Train"},{"key":"bibr16-15347346211018330","volume":"12","author":"Mazumdar S","year":"2019","journal-title":"JTCM"},{"key":"bibr17-15347346211018330","volume":"2018","author":"Demilew W","year":"2018","journal-title":"eCAM"},{"key":"bibr18-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"bibr19-15347346211018330","volume":"2011","author":"Datta HS","year":"2011","journal-title":"Evi Based Complement Alternat Med"},{"key":"bibr20-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-849-2_4"},{"issue":"3","key":"bibr21-15347346211018330","first-page":"53","author":"Nayan S","year":"2019","journal-title":"IJPER"},{"key":"bibr22-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(96)00131-8"},{"key":"bibr23-15347346211018330","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.81978"},{"key":"bibr24-15347346211018330","first-page":"32","volume":"2","author":"Singh MP","year":"2010","journal-title":"Pharmacologyonline"},{"key":"bibr25-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000014"},{"key":"bibr26-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3406215"},{"key":"bibr27-15347346211018330","doi-asserted-by":"publisher","DOI":"10.4103\/0975-2870.206569"},{"key":"bibr28-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.04.042"},{"key":"bibr29-15347346211018330","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2018.5.149"},{"key":"bibr30-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0517"},{"key":"bibr31-15347346211018330","doi-asserted-by":"publisher","DOI":"10.4103\/2347-9264.165438"},{"key":"bibr32-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.04.023"},{"key":"bibr33-15347346211018330","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00036.x"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346211018330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346211018330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346211018330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:04:39Z","timestamp":1777457079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346211018330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,14]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/15347346211018330"],"URL":"https:\/\/doi.org\/10.1177\/15347346211018330","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,14]]}}}