{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:26:15Z","timestamp":1783463175473,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    Background. Chronic foot ulcers are a major cause of morbidity in people with diabetes with a lifetime risk of 25%. Treatment is challenging and the recurrence rates of foot ulcers are &gt;50% after 3 years. Vitamin D deficiency is more common in people with diabetes with chronic foot ulcers, compared to both people without diabetes as well as people with diabetes but without foot ulcers. Purpose\/aim of study. To assess the efficacy of high-dose compared to low-dose Cholecalciferol vitamin D3 on healing of chronic diabetic foot ulcers. Materials and methods. We included people with diabetes with one or more foot ulcers lasting for more than 6 weeks. Patients were randomly allocated to either a daily oral intake of high-dose (170 \u03bcg) or low-dose (20 \u03bcg) vitamin D3 (Cholecalciferol). We saw patients in the outpatient clinic after 4, 12, 24, 36, and 48 weeks. At each visit, we measured the ulcer with a specialized camera, and associated software and the area (cm\n                    <jats:sup>2<\/jats:sup>\n                    ) was calculated. Patients and assessors were blinded to treatment allocation. We followed all patients for 48 weeks or until wound healing or surgical treatment. Findings\/results. We included 48 patients in the analysis (24 in each group), with a total of 64 ulcers. Among them 41 ulcers were followed until healing or 48-week follow-up and 20 ulcers were surgically treated during the study period. Three patients were lost for follow-up. The intention-to-treat analysis showed a significantly higher rate of ulcer healing in the high-dose group with 21 of 30 (70%) healed ulcers compared to 12 of 34 (35%) in the low-dose group ( P\u2009=\u2009.012). Median ulcer reduction at final follow-up was 100% (interquartile range [IQR]: 72-100) in the high-dose group and 57% (IQR: \u221228 to 100) in the low-dose group. Furthermore, we found a significant effect of high-dose vitamin D on ulcer reduction in the repeated measures analysis of variance. Conclusions. We found high-dose vitamin D3 to be efficient, compared to low-dose vitamin D3, in promoting healing in chronic diabetic foot ulcers.\n                  <\/jats:p>","DOI":"10.1177\/15347346211020268","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T13:11:34Z","timestamp":1625231494000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-353X","authenticated-orcid":false,"given":"Peter M.","family":"Halschou-Jensen","sequence":"first","affiliation":[{"name":"Herlev and Gentofte University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannie","family":"Sauer","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, K\u00f8ge, Sj\u00e6lland, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bouchelouche","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, K\u00f8ge, Sj\u00e6lland, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Fabrin","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, K\u00f8ge, Sj\u00e6lland, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-758X","authenticated-orcid":false,"given":"Stig","family":"Brorson","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, K\u00f8ge, Sj\u00e6lland, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Ohrt-Nissen","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, K\u00f8ge, Sj\u00e6lland, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"bibr1-15347346211020268","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"bibr2-15347346211020268","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2013.06.008"},{"key":"bibr3-15347346211020268","first-page":"13","author":"Reiber GE","year":"2001","journal-title":"Diabet 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