{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:15:59Z","timestamp":1789229759336,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Dermcidin, salusin-\u03b1, and salusin-\u03b2 are three recently discovered molecules that confer antimicrobial properties. The present study aims to investigate the association between dermcidin, salusin-\u03b1, and salusin-\u03b2 in the etiopathology of patients with diabetic foot infection. The study included three groups: Group 1 - diabetic foot infection; Group 2 - diabetes without history of diabetic foot; and Group 3 \u2013 the control group. Plasma dermcidin, salusin-\u03b1, and salusin-\u03b2 levels were compared across the groups. Median (Q1-Q3) values of plasma dermcidin levels in Groups 1, 2, and 3 were 3.45 (0.8-4.4), 5.2 (3.7-6.4), and 5.8 (3.1-10) ng\/mL, respectively. Diabetic foot infection group had significantly lower plasma dermcidin levels compared to diabetes only group and control group ( P\u2009=\u2009.000, ANOVA), whereas there was no statistically significant difference between the Group 2 and Group 3 ( P\u2009=\u2009.163, ANOVA). Salusin-\u03b1 and salusin-\u03b2 levels were significantly higher in the Group 3 compared to the other groups. Based on our findings, diabetic foot infection group had significantly lower plasma dermcidin levels and salusin-\u03b1 and salusin-\u03b2 levels were significantly higher in the control group. These molecules (dermcidin specifically) can be researched as an adjuvant therapeutic agent in addition to conventional treatments in diabetic foot diabetic foot infections. Also, it can be searched this may prevent many complications including amputation.<\/jats:p>","DOI":"10.1177\/15347346211065527","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T04:52:35Z","timestamp":1639975955000},"page":"450-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Dermcidin, Salusin-\u03b1, Salusin-\u03b2 Molecules and Diabetic Foot Infections"],"prefix":"10.1177","volume":"23","author":[{"given":"Ay\u015fe","family":"Sa\u011fmak Tartar","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kader","family":"U\u011fur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Firat University, Elazig, 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