{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:00:04Z","timestamp":1790564404555,"version":"4.1.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    Venous leg ulcers (VLUs) are chronic and recalcitrant lower limb wounds that affect millions of patients annually, severely reducing their quality of life, and causing a significant burden on the health care system. Recently, Platelet rich plasma (PRP) has been used to improve healing of VLUs. This systematic review aimed at evaluating the effectiveness of PRP versus the standard of care commonly used to treat VLUs. Ten prospective studies (8 randomized) met the inclusion criteria comprising 451 patients with 527 VLUs. Results were as follows: a) the weighted Odds Ratio (OR) of the mean healing rate was 2.84 (95% CI\u2009=\u20091.160 to 5.056, I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200941.4%, p\u2009=\u20090.0004), b) the mean healed ulcer areas were 79.2\u2009\u00b1\u200919% for the PRP group and 51.7\u2009\u00b1\u200936% for the control group (p\u2009=\u20090.007) in favor of the PRP group, and c) the weighted infection OR showed no significant difference between both groups. Additionally, negative correlations were found between healing rate\n                    <jats:italic>and<\/jats:italic>\n                    duration of VLUs and initial size of the ulcers. This meta-analysis demonstrated significant beneficial effects of PRP versus standard of care on healing rate, reduction in surface, and reduction in healing time of VLUs. Infection and other complications were similar to standard of care. Therefore, our analytical data would support the use of PRP as a safe and effective treatment for VLUs.\n                  <\/jats:p>","DOI":"10.1177\/15347346221094424","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T01:50:34Z","timestamp":1649987434000},"page":"260-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["PRP Versus Standard of Care for Venous leg Ulcers: A Systematic Review and Meta-Analysis of Prospective Comparative Studies"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-9892","authenticated-orcid":false,"given":"Kaissar","family":"Yammine","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon"},{"name":"Diabetic Foot Clinic, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon"},{"name":"Center for Evidence-Based Anatomy, Sport &amp; Orthopedics Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-600X","authenticated-orcid":false,"given":"Joe","family":"Ghanimeh","sequence":"additional","affiliation":[{"name":"Observer doctor at the Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sira","family":"Jil Agopian","sequence":"additional","affiliation":[{"name":"Observer doctor at the Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahine","family":"Assi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon"},{"name":"Center for Evidence-Based Anatomy, Sport &amp; Orthopedics Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Hayek","sequence":"additional","affiliation":[{"name":"Vascular Division, Department of General Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"1902","article-title":"Venous leg ulcers","volume":"2016","author":"Nelson EA","year":"2016","unstructured":"Nelson EA, Adderley U. 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