{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:00:18Z","timestamp":1777712418980,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    The objective of this work was to investigate impact of Cinnamon nanoparticles loaded on chitosan- gelatin nanoparticles on burn wound healing in diabetic foot ulcers in rat. We included sixty male rats into four groups. There were 15 animals in each group as follow: DFU group: We treated the burn wounds with normal saline (0.1\u2005mL). DFU\/SSD group: In this group, the wounds were with silver sulfadiazine 1% ointment. DFU\/CGNP: In this group, the burn wounds were treated with chitosan-gelatin nanoparticles based ointment (0.05\u2005mg\/mL). DFU\/CNP-CGNP group: In this group, the wounds were treated with CN-CGNPs (0.05\u2005mg\/mL). Wound area reduction measurements, biochemistry, histomorphometrical studies, hydroxyproline levels and reverse transcription polymerase chain reaction for caspase 3, Bcl-2, and p53 showed significant difference between rats in DFU\/CNP-CGNP group in comparison with other groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Accelerated repair of the wounds in DFU\/CNP-CGNP group showed that local application of Cinnamon nanoparticles loaded on chitosan- gelatin nanoparticles could be taken into consideration in burn wound healing in diabetic foot ulcers.\n                  <\/jats:p>","DOI":"10.1177\/15347346221101245","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:59:26Z","timestamp":1654477166000},"page":"466-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cinnamon Nanoparticles Loaded on Chitosan- Gelatin Nanoparticles Enhanced Burn Wound Healing in Diabetic Foot Ulcers in Rats"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-8863","authenticated-orcid":false,"given":"Amirreza","family":"Hajati Ziabari","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Asadi Heris","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed","family":"Mohammad Doodmani","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Jahandideh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-9453","authenticated-orcid":false,"given":"Kave","family":"Koorehpaz","sequence":"additional","affiliation":[{"name":"Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahim","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.382"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v4i0.21847"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.071"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193473"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119636"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-00235-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.04.020"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201033489748"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.08.056"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36806"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.11.017"},{"issue":"3","key":"e_1_3_3_16_2","first-page":"659","article-title":"Improvement of curcumin solubility by polyethylene glycol\/chitosan-gelatin nanoparticles (CUR-PEG\/CS-G-nps)","volume":"27","author":"Farnia P","year":"2016","unstructured":"Farnia P, Mollaei S, Bahrami A, et al. 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