{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:01:23Z","timestamp":1777712483754,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["1037918"],"award-info":[{"award-number":["1037918"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Chronic ulcers are a major public health problem, due to their chronic nature, their poor response to treatment, the high frequency of recurrences, and their affection to the patient\u2019s quality of life. Even with the development of new therapies in the field of chronic wound care, chronic ulcers remain a clinical problem. As a novel branch of research, Catalytic Nanomedicine has offered promising results in disinfection and treatment of chronic wounds through the use of bionanocatalysts, organically functionalized mesoporous nanostructured materials with catalytic properties. Particularly, Cu\/TiO\n                    <jats:sub>2<\/jats:sub>\n                    -SiO\n                    <jats:sub>2<\/jats:sub>\n                    mixed oxide bionanocatalysts have shown favorable results for chronic ulcer healing. In this work, we present the treatment of 15 patients (8 females and 7 males, mean age of 69.59\u2009\u00b1\u200912.07 years old) affected with chronic ulcers (wound age ranging from 4 months to 10 years old, mean size of 12.94\u2009\u00b1\u200918.20 cm\n                    <jats:sup>2<\/jats:sup>\n                    ) by the administration of Cu\/TiO\n                    <jats:sub>2<\/jats:sub>\n                    -SiO\n                    <jats:sub>2<\/jats:sub>\n                    bionanocatalysts embedded in a nanoemulsion matrix. In all cases, complete epithelialization and healing of the lesions was achieved (healing time from 3 to 35 weeks), without the appearance of side effects. Wound healing time was analyzed in the context of initial wound size, wound\u2019s age, patient\u2019s age, and concomitant conditions, being wound size and patient\u2019s age the main factor affecting the duration of the treatment with the bionanocatalysts.\n                  <\/jats:p>","DOI":"10.1177\/15347346221119006","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T03:55:12Z","timestamp":1660017312000},"page":"1229-1238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Catalytic Nanomedicine \u2013 A new Approach and Solution for Chronic Ulcers: Case Series"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-0419","authenticated-orcid":false,"given":"Tessy","family":"L\u00f3pez-Goerne","sequence":"first","affiliation":[{"name":"Autonomous Metropolitan University-Xochimilco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Autonomous Metropolitan University-Xochimilco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Clinic Specializing in Venous Ulcers, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireya","family":"Huantes","sequence":"additional","affiliation":[{"name":"Clinic Specializing in Venous Ulcers, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Padilla-God\u00ednez","sequence":"additional","affiliation":[{"name":"Autonomous Metropolitan University-Xochimilco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Andrews\u2019 Diseases of the Skin: Clinical Dermatology","author":"James W","unstructured":"James W, Elston D, Treat J, et al. Andrews\u2019 Diseases of the Skin: Clinical Dermatology. 13th ed. Sanders, Elsevier; 2019.","edition":"13"},{"key":"e_1_3_2_3_2","first-page":"413604","article-title":"Chronic leg ulcers: epidemiology, aetiopathogenesis, and management","volume":"2013","author":"Frade MAC","year":"2013","unstructured":"Frade MAC. Chronic leg ulcers: epidemiology, aetiopathogenesis, and management. Ulcers. 2013;2013(14):413604.","journal-title":"Ulcers"},{"key":"e_1_3_2_4_2","first-page":"298","article-title":"Venous ulcers: diagnosis and treatment","volume":"100","author":"Millan SB","year":"2019","unstructured":"Millan SB, Gan R, Townsend PE. Venous ulcers: diagnosis and treatment. 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Manual de prevenci\u00f3n y cuidados locales de heridas cr\u00f3nicas [Manual of prevention and local care of chronic wounds]. Servicio C\u00e1ntabro de Salud; 2011."},{"key":"e_1_3_2_23_2","first-page":"60","article-title":"The importance of continuous wound measuring","volume":"2","author":"Gethin G","year":"2006","unstructured":"Gethin G. The importance of continuous wound measuring. Wounds International. 2006;2(2):60-68.","journal-title":"Wounds International"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30227-4"},{"key":"e_1_3_2_25_2","first-page":"1","volume-title":"Therapeutic Dressings and Wound Healing Applications","author":"Tate S","unstructured":"Tate S, Harding K. Chronic wound healing: molecular and biochemical basis. In: Therapeutic Dressings and Wound Healing Applications. 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