{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:32:12Z","timestamp":1793773932871,"version":"4.6.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical characteristic application research","award":["Z181100001718027"],"award-info":[{"award-number":["Z181100001718027"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    With younger onset age of type 2 diabetes mellitus (T2DM), the incidence of diabetic foot ulcer (DFU) in young and middle-aged adults is also increasing. Elucidating the distinctive characteristics of DFU in different ages and exploring the influence of age on the prognosis of DFU are crucial to the improvement of DFU treatments.\n                    <jats:bold>Methods:<\/jats:bold>\n                    684 patients hospitalized for DFU in the department of endocrinology were recruited and assigned into the young and middle-aged group (age &lt;65 years old) and the elderly group (age \u226565 years old). Demographic data and clinical features were compared between two groups.\n                    <jats:bold>Results:<\/jats:bold>\n                    Compared with the elderly group, the young and middle-aged group had higher proportion of males (72.3% vs 49.6%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01) and smokers (52.5% vs 35.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01), shorter duration of diabetes mellitus (155 months vs 196 months,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01), higher levels of glycosylated hemoglobin (9.3% vs 8.7%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01), lower ratio of ankle-brachial index &lt;0.9 (25.8% vs 51.1%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.01) and higher levels of c-reactive protein and erythrocyte sedimentation rate (14\u2005mg\/L vs 10\u2005mg\/L,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05; 36\u2005mm\/h vs 30\u2005mm\/h,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). The prevalence of diabetic peripheral neuropathy and Wagner Grade were similar in two groups. Of note, the prognosis was similar in different age groups, as there were no significant differences in the healing rate (59.7% vs 60.1%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u2009.05), healing time (30 days vs 22 days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u2009.05) and minor amputation rate (11.9% vs 8.7%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u2009.05).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    We found that no evidence to suggest a better prognosis with younger DFU patients. Compared with elderly ones, young and middle-aged patients were characterized by a higher proportion of smoking, worse glycemic control, higher inflammatory biomarkers but less severe lower limb ischemia, indicating that smoking cessation, strict blood glucose control and early detection of infection were crucial for improving the prognosis of young and middle-aged diabetic DFU patients.\n                  <\/jats:p>","DOI":"10.1177\/15347346221125844","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T03:01:27Z","timestamp":1664766087000},"page":"985-993","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Prognosis of Diabetic Foot Ulcer is Independent of age? A Comparative Analysis of the Characteristics of Patients with Diabetic Foot Ulcer in Different age Groups: A Cross-Sectional Study from China"],"prefix":"10.1177","volume":"24","author":[{"given":"Lintao","family":"Shi","sequence":"first","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-8444","authenticated-orcid":false,"given":"Jing","family":"Xue","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"},{"name":"306th Clinical College of PLA, The Fifth Clinical Medical College, Anhui Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"},{"name":"306th Clinical College of PLA, The Fifth Clinical Medical College, Anhui Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wei","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Li","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-102X","authenticated-orcid":false,"given":"Aihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Diabetes Center of People\u2019s Liberation Army (PLA), Department of Endocrinology, PLA Strategic Support Force Medical Center, Beijing, China"},{"name":"306th Clinical College of PLA, The Fifth Clinical Medical College, Anhui Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"4106383","article-title":"Prevalence of diabetic foot ulcer and associated factors among adult diabetic patients on follow-up clinic at Jimma Medical Center, Southwest Ethiopia, 2019: An institutional-based cross-sectional study","volume":"2020","author":"Abdissa D","year":"2020","unstructured":"Abdissa D, Adugna T, Gerema U, Dereje D. Prevalence of diabetic foot ulcer and associated factors among adult diabetic patients on follow-up clinic at Jimma Medical Center, Southwest Ethiopia, 2019: An institutional-based cross-sectional study. J Diabetes Res. 2020;2020:4106383.","journal-title":"J Diabetes Res."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2011.00135.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000795"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12932"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/107110078100200202"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1303"},{"issue":"5","key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified airlie house classification. ETDRS report number 10. 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Risk factors associated with healing chronic diabetic foot ulcers: The importance of hyperglycemia","volume":"52","author":"Marston WA","year":"2006","unstructured":"Marston WA, Dermagraft diabetic foot ulcer study G. Risk factors associated with healing chronic diabetic foot ulcers: The importance of hyperglycemia. 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