{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:09:26Z","timestamp":1791871766229,"version":"4.3.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Diabetic foot is a serious complication of diabetes which has significant medical and socioeconomic impacts. Turmeric is a popular Indian spice that has been used for centuries in herbal medicines for the treatment of a variety of ailments such as rheumatism, diabetic ulcers, anorexia, cough and sinusitis. Curcumin is the main ingredient presents in turmeric and responsible for its yellow color. We report here a randomized, placebo-controlled investigation into the effectiveness of topical turmeric ointment in the treatment of diabetic foot ulcers. Seventy-six patients enrolled in the study. They were randomly divided into two groups, one of which received topical turmeric ointment and the other received placebo. Preparations were applied twice daily after irrigation of the wound by normal saline and dressed. Image analysis software was used to evaluate photographs of the ulcers and quantify the difference between treatment and placebo groups. Topical turmeric ointment demonstrated statistically significant reduction (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.001) in the size of diabetic ulcers at five weeks compared to placebo, independently of fasting blood sugar and HbA1C levels. Turmeric ointment may be an effective treatment for diabetic foot ulcers.\n                  <\/jats:p>","DOI":"10.1177\/15347346221143222","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T01:29:21Z","timestamp":1670981361000},"page":"1063-1067","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Topical Turmeric Ointment in the Treatment of Diabetic Foot Ulcers: A Randomized, Placebo-Controlled Study"],"prefix":"10.1177","volume":"24","author":[{"given":"Mohsen","family":"Agharazi","sequence":"first","affiliation":[{"name":"Saveh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-2466","authenticated-orcid":false,"given":"Sasan","family":"Gazerani","sequence":"additional","affiliation":[{"name":"Saveh University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Kenneth","family":"Huntington","sequence":"additional","affiliation":[{"name":"Medicine, University of South Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001"},{"issue":"1","key":"e_1_3_3_5_2","first-page":"1","article-title":"Overview of diabetic foot; novel treatments in diabetic foot ulcer","volume":"16","author":"Ranjbar H","year":"2008","unstructured":"Ranjbar H. Overview of diabetic foot; novel treatments in diabetic foot ulcer. DARU. 2008;16(Suppl. 1):1-6.","journal-title":"DARU."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-8-59"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-012-0004-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.016"},{"issue":"1","key":"e_1_3_3_9_2","first-page":"44","article-title":"Turmeric and curcumin: Biological actions and medicinal applications","volume":"87","author":"Chattopadhyay I","year":"2004","unstructured":"Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Curr Sci. 2004;87(1):44-53.","journal-title":"Curr Sci."},{"issue":"1","key":"e_1_3_3_10_2","first-page":"15","article-title":"Antibacterial activity of plants belonging to Zingiberaceae family","volume":"16","author":"Thomas E","year":"1996","unstructured":"Thomas E. Antibacterial activity of plants belonging to Zingiberaceae family. Biomedicine. 1996;16(1):15-20.","journal-title":"Biomedicine."},{"issue":"5","key":"e_1_3_3_11_2","first-page":"1","article-title":"Comparison of antimicrobial effects of Curcuma Longa extract and selective antibiotics against bacteria isolated from infected burn wounds","volume":"16","author":"Attarpouryazdi M","year":"2009","unstructured":"Attarpouryazdi M, Kamalinejad M, Falvaei Kouchak NS. Comparison of antimicrobial effects of Curcuma Longa extract and selective antibiotics against bacteria isolated from infected burn wounds. Daneshvar Med. 2009;16(5):1-10.","journal-title":"Daneshvar Med."},{"issue":"1","key":"e_1_3_3_12_2","first-page":"0","article-title":"The anti-inflammatory effects of the Curcuma longa extract in experimental model of inflammation","volume":"7","author":"Ranjbar A","year":"2009","unstructured":"Ranjbar A, Ranjabar M. The anti-inflammatory effects of the Curcuma longa extract in experimental model of inflammation. Pars J Med Sci. 2009;7(1):0-0.","journal-title":"Pars J Med Sci"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3500"},{"issue":"3","key":"e_1_3_3_14_2","first-page":"36","article-title":"Comparison of honey dressing with hydrocolloid dressing effects on pressure ulcer healing of ICU hospitalized patients","volume":"1","author":"Mehrabani H","year":"2012","unstructured":"Mehrabani H, Hosseini MA, Nourozi K, Karimloo M. Comparison of honey dressing with hydrocolloid dressing effects on pressure ulcer healing of ICU hospitalized patients. J Health Promot Manag. 2012;1(3):36-46.","journal-title":"J Health Promot Manag."}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346221143222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346221143222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346221143222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:34Z","timestamp":1777457134000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346221143222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/15347346221143222"],"URL":"https:\/\/doi.org\/10.1177\/15347346221143222","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}