{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:01:49Z","timestamp":1777712509941,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To monitor wound pH and surface temperature as predictors of wound healing in diabetic foot ulcers (DFU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective, observational, time-bound study of 18 months, enrolling patients aged 18 to 60 years with uninfected DFU. The wound was assessed at baseline and after that, every week for 4 weeks according to the leg ulcer measurement tool (LUMT). Concurrently, wound surface pH and temperature were measured. The data were analyzed using descriptive statistics, and a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009&lt;\u2009.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-four patients with DFU were included in the study with a mean age of 55 years and a male to female ratio of 1.57. The wound showed progressive improvement, a maximum mean LUMT score of 48.89 (\u00b1 2.81) at the initial evaluation and decreased progressively to the mean of 19.80 at week 4 (\u00b1 3.43), both of which were statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009&lt;\u2009.001). Similarly, the median wound pH progressively reduced from 7.7 at baseline to 7.20 in the fourth week, and median wound temperature decreased from 90\u00b0F (32.22\u2005\u00b0C) at baseline to 85\u00b0F (29.44\u2005\u00b0C) in the fourth week, both of which were statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Progressive and significant change in wound pH to acidic and drop in wound surface temperature, both corresponding to improvement in the status of DFU, maximum at 4 weeks, make them valuable predictors of wound healing. However, further, more extensive studies are required to establish a concrete relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346231156962","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T07:59:27Z","timestamp":1677052767000},"page":"1129-1139","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers"],"prefix":"10.1177","volume":"24","author":[{"given":"Bhavani","family":"Prasad Mahindrakar","sequence":"first","affiliation":[{"name":"Himalayan Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-7832","authenticated-orcid":false,"given":"Aakansha Giri","family":"Goswami","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-1832","authenticated-orcid":false,"given":"Farhanul","family":"Huda","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Naithani","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somprakas","family":"Basu","sequence":"additional","affiliation":[{"name":"Himalayan Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Saeedi P Petersohn I Salpea P et al. IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas 9th edition. Diabetes Res Clin Pract. 2019;157:107843.","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_2_3_2","unstructured":"World Health Organization. Global report on diabetes. France: 2016. [cited 20 January 2021]. In: World Health Organization [Internet]. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241565257."},{"key":"e_1_3_2_4_2","unstructured":"International Diabetes Federation. Clinical Practice Recommendation on the Diabetic Foot: A guide for health care professionals. 2017:1-70 [cited 18 January 2021]. In: International Diabetes Federation [Internet]. 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