{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:36:31Z","timestamp":1788294991926,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    We aimed to evaluate the value of 2 peripheral blood cell ratios, the mean platelet volume-to-lymphocyte ratio (MPVLR) and the neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers of mortality in patients with diabetic foot infections (DFIs). We conducted a prospective observational study consisting of a cohort of 200 patients with moderate to severe DFIs consecutively recruited from our Diabetic Foot Unit, Hospital San Juan de Dios, San Jos\u00e9 de Costa Rica, Costa Rica from October 15, 2020, to December 15, 2021. We studied the variables associated with one-year all-cause mortality using a multivariate backward Cox\u2019s regression model. Nonparametric Spearman Rho was used to study the linear correlation between NLR and MPVLR and other inflammatory markers. The variables associated with all-cause mortality were retinopathy (hazard ratio [HR]: 2.55, 95% confidence interval [CI]: 1.22-5.33,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.01), estimated glomerular filtration rate (HR: 0.979, 95% CI: 0.969-0.990,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    &lt;\u2009.001), HbA1c (HR: 0.825, 95% CI: 0.702-0.969,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.01), and MPVLR (HR: 1.093, 95% CI: 1.020-1.172,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.01). NLR showed a strong correlation with white blood cell count (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.60 [&lt;0.001]) and c-reactive protein (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.63 [&lt;0.001]), and a weak correlation with erythrocyte sedimentation rate (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.33 [&lt;0.001]), though it was not associated with mortality. In conclusion, apart from other risk factors of mortality, we have for the first time demonstrated that the increasing value of MPVLR is a factor associated with one-year mortality in patients with DFIs.\n                  <\/jats:p>","DOI":"10.1177\/15347346231165668","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T02:41:25Z","timestamp":1679971285000},"page":"1159-1164","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Mean Platelet Volume-to-Lymphocyte Ratio Is a Biomarker of 1-Year Mortality in Patients With Diabetic Foot Infections"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-5040","authenticated-orcid":false,"given":"Javier","family":"Arag\u00f3n-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Surgery, Diabetic Foot Unit, La Paloma Hospital, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"V\u00edquez-Molina","sequence":"additional","affiliation":[{"name":"Diabetic foot Unit, San Juan de Dios Hospital, San Jos\u00e9 de Costa Rica, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-9729","authenticated-orcid":false,"given":"Mar\u00eda Eugenia","family":"L\u00f3pez-Valverde","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Juan Ram\u00f3n Jimenez Hospital, Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Arag\u00f3n-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Geriatrics Service, Getafe University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Arag\u00f3n-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Diabetic Foot Unit, La 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