{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:14:13Z","timestamp":1790475253720,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Diabetic foot ulcer (DFU) is globally a major health burden predisposing to limb amputation. Among the various treatment modalities, platelet-rich plasma (PRP) is emerging as a promising agent. It stimulates wound healing by providing a higher concentration of essential growth factors locally. Though the role of PRP in DFU healing is established, still the route of administration with maximal efficacy is yet to be defined. Our study aims to evaluate the efficacy of autologous PRP in the treatment of diabetic ulcers and compare the effect of topical and perilesional injections of PRP in DFU healing. We conducted a single-centre, prospective, interventional study on 60 patients with DFU, in 2 groups of 30 patients each. They were treated with freshly prepared autologous PRP injection perilesionally and topically respectively, once a week for 4 weeks. Ulcer size was assessed, using \u201cimito-measure\u201d software at presentation and 2, 4, 8, and 12 weeks post-therapy. Serum MMP-9 levels were assessed in both groups, pretreatment and post-treatment. For statistical analysis, SPSS software V-23 was used. On assessment, both groups had comparable baseline characteristics, Wagner's grading, and glycemic indices. The percentage reduction in the size of the wound at 2 weeks, 1 month, 2 months, and 3 months was greater in the perilesional group as compared to the topical PRP group.<\/jats:p>","DOI":"10.1177\/15347346231176727","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:04:01Z","timestamp":1684980241000},"page":"1188-1197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A Comparative Evaluation of Topical Application Versus Perilesional Injection of Platelet-Rich Plasma in Diabetic Foot Ulcer"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-4074","authenticated-orcid":false,"given":"Digumarthi Asha","family":"Rani","sequence":"first","affiliation":[{"name":"Department of General Surgery, Institute of medical sciences, Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Khanna","sequence":"additional","affiliation":[{"name":"Institute of medical sciences, Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Banaras Hindu University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.03.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050748"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-012-0004-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0324-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.716184"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.15226\/2374-6904\/4\/2\/00156"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3914"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14138"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13361"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3126\/nje.v6i2.15160"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.5758\/vsi.2019.35.1.22"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v9.i10.172"},{"issue":"8","key":"e_1_3_2_14_2","first-page":"136","article-title":"Effects of intra-lesional injection of platelet rich plasma (PRP) on healing of diabetic foot ulcers","volume":"3","author":"Abdelhafez AA","year":"2016","unstructured":"Abdelhafez AA, Ragab A, Younes H, Nasser M, Khereba W. Effects of intra-lesional injection of platelet rich plasma (PRP) on healing of diabetic foot ulcers. Int Inv J Med Med Sci. 2016;3(8):136\u2010142.","journal-title":"Int Inv J Med Med Sci"},{"issue":"6","key":"e_1_3_2_15_2","first-page":"597","article-title":"Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity","volume":"105","author":"Salazar-\u00c1lvarez AE","year":"2014","unstructured":"Salazar-\u00c1lvarez AE, Riera-Del-Moral LF, Garc\u00eda-Arranz M, Alvarez-Garc\u00eda J, Concepci\u00f3n-Rodriguez NA, Riera-De-Cubas L. Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity. 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