{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:06:05Z","timestamp":1790085965889,"version":"4.0.1"},"reference-count":7,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    The systemic immune-inflammation index (SII) was significantly higher in patients with severe infections, those with necrosis, and in those requiring admission, postoperative antibiotics, and any amputation. However, SII was significantly lower in patients with osteomyelitis compared to those with soft tissue infections. The correlation coefficients (rho) between SII and other inflammatory markers were as follows: WBC (Moderate correlation, 0.64,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), ESR (Weak correlation, 0.34,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), and CRP (Moderate correlation, 0.56,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). The correlation coefficient (rho) between SII and the number of days admitted was moderate, 0.42 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Based on a previous experience, SII may be an additional marker to diagnose osteomyelitis in the feet of patients with diabetes. Now, we need further research including SII, a low-cost and easy-to-measure index, in well-designed controlled studies to definitively clarify its role.\n                  <\/jats:p>","DOI":"10.1177\/15347346231179280","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T05:14:52Z","timestamp":1685682892000},"page":"1278-1280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Systemic Immune-Inflammation Index in Diabetic Foot Infections and Osteomyelitis"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-5040","authenticated-orcid":false,"given":"Javier","family":"Arag\u00f3n-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Hospital Policlinico La Paloma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"V\u00edquez-Molina","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, San Juan de Dios Hospital, San Jos\u00e9 de Costa Rica, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-9729","authenticated-orcid":false,"given":"Mar\u00eda Eugenia","family":"L\u00f3pez-Valverde","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service, Juan Ram\u00f3n Jimenez Hospital, Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Rojas-Bonilla","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, San Juan de Dios Hospital, San Jos\u00e9 de Costa Rica, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221130817"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14648"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346231154472"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221116740"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03150.x"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346231179280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346231179280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346231179280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:40Z","timestamp":1777457140000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346231179280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/15347346231179280"],"URL":"https:\/\/doi.org\/10.1177\/15347346231179280","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]}}}