{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:02:54Z","timestamp":1777712574645,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>Escin, a naturally derived material isolated from horse chestnut, is used as an anti-inflammatory and anti-edema agent. This study aimed to evaluate its effects on lymphedema in a rat tail model. We divided the rats into five groups. The treatment groups received topical application of escin gel at concentrations of 20%, 10%, 2%, and 0.5% for 4 weeks. The fifth group served as a control. We performed volumetric (water displacement) tests, H&amp;E staining, and LYVE-1 immunohistochemical staining, followed by statistical evaluation. All treatment groups showed significant volumetric reductions compared with the control group, but no significant differences were observed between the treatment groups. H&amp;E staining showed a significant reduction in dermal thickness in the 20%, 10%, and 2% escin treatment groups compared to the control group. Within the treatment groups, the 2% escin group showed a significant difference compared with the 20% and 10% escin groups (p\u2009=\u20090.021 for both). LYVE-1 immunohistochemical staining revealed a significantly higher mean lymphatic vessel count in the 2% escin group compared with the 20%, 10%, and 0.5% escin-treated groups and the control group (p\u2009=\u20090.019, p\u2009=\u20090.025, p\u2009=\u20090.019, and p\u2009=\u20090.032 respectively). Topical escin applied to a rat tail model of acute lymphedema resulted in a significant reduction in tail volume, reduced dermal thickness, and increased lymphatic structures. The 2% escin concentration may be the optimal dose for improving lymphedema in this model. Further research is warranted to explore the clinical application of escin in patients with lymphedema.<\/jats:p>","DOI":"10.1177\/15347346231195944","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:18:06Z","timestamp":1692674286000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Escin as a Topical Agent for Lymphedema Treatment in a Rat Model"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-6506","authenticated-orcid":false,"given":"Hyung Hwa","family":"Jeong","sequence":"first","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donggeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taehyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyunSuk Peter","family":"Suh","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangSik John","family":"Pak","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Pio","family":"Hong","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1323762"},{"issue":"1","key":"e_1_3_3_4_2","first-page":"18","article-title":"Lymphedema secondary to breast cancer: how choice of measure influences diagnosis, prevalence, and identifiable risk factors","volume":"41","author":"Hayes S","year":"2008","unstructured":"Hayes S, Janda M, Cornish B, Battistutta D, Newman B. 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