{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:02:44Z","timestamp":1777712564118,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Science and Technology Project of Chengguan district of Lanzhou City","award":["2021-2-6"],"award-info":[{"award-number":["2021-2-6"]}]},{"name":"Cuiying Scientific and the Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2022-HL-A04"],"award-info":[{"award-number":["CY2022-HL-A04"]}]},{"name":"the scientific research project of the Chinese Nursing Association","award":["ZHKYQ202202"],"award-info":[{"award-number":["ZHKYQ202202"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To evaluate the reliability of the methodological quality and outcome measures of systematic reviews (SRs)\/metaanalyses (MAs) of the acellular dermal matrix (ADM) for diabetic foot ulcer (DFU).\n                    <jats:bold>Methods:<\/jats:bold>\n                    We searched and retrieved SRs and MAs on the application of ADM for DFU from PubMed, Web of Science, The Cochrane Library, EMBASE, CNKI, CBM, WanFang, and VIP databases. We employed AMSTAR 2 to assess methodological quality, Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system to grade, and the strength of evidence of included SRs\/MAs. We excluded the overlapping randomized controlled trials (RCTs) and conducted a re-MA of the primary RCTs.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 7 SRs\/MAs were included. Results from the AMSTAR 2 evaluation revealed a low overall quality; the GRADE system showed that the evidence was of moderate to very low quality. Our re-MA showed that ADM was superior to standard of care (SOC), with regards to complete wound healing rate at 12 weeks (RR\u2009=\u20091.74, 95% CI:1.34-2.25,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    &lt;\u2009.0001), complete wound healing rate at 16 weeks (RR\u2009=\u20091.50, 95% CI: 1.26-1.77,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    \uff1c\u2009.00001); healing time (MD\u2009=\u2009\u22122.06, 95% CI: \u22122.57 to \u22121.54,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    &lt;\u2009.00001) and adverse events (RR\u2009=\u20090.62, 95% CI: 0.49-0.80,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.0002). However, a consensus has not yet been reached between ADM and SOC groups with regard to outcome indicators of the reduction of ulcer area and quality of life; and subgroup analyses showed no statistically significant differences between the xenograft ADM and SOC groups (RR\u2009=\u20091.36, 95% CI: 0.95-1.93,\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.09) at 12 weeks.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Current evidence suggests that ADM is more effective than the standard of care in the treatment of DFU, particularly for full-thickness, noninfected, and nonischemic foot ulcers, but with low evidence quality. Therefore, the results of this overview should be interpreted dialectically and prudently, and the role of ADM in DFU needs further exploration.\n                  <\/jats:p>","DOI":"10.1177\/15347346231201696","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T01:54:10Z","timestamp":1701222850000},"page":"19-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acellular Dermal Matrix for Treatment of Diabetic Foot Ulcer: An Overview of Systematic Reviews"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-1373","authenticated-orcid":false,"given":"Li","family":"Lingyan","sequence":"first","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Han","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jialu","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Bingyang","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Yuanyuan","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Peiwei","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1221-3212","authenticated-orcid":false,"given":"Ma","family":"Peifen","sequence":"additional","affiliation":[{"name":"School of Nursing, Lanzhou University"},{"name":"The Second Hospital of Lanzhou University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liwei","sequence":"additional","affiliation":[{"name":"Department of Burns, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, P. 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