{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:12:44Z","timestamp":1793326364307,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic wounds, including diabetic ulcers, posttraumatic ulcers, and pressure sores, present a significant challenge in healthcare due to their complex nature and resistance to conventional treatments. This retrospective observational study aimed to evaluate the efficacy of an ointment containing hyaluronic acid and collagenase in treating such wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 70 patients with various chronic wounds treated in our clinic from January 1, 2020, to October 1, 2023. The patients were selected according to specific inclusion and exclusion criteria, and comprehensive baseline data was collected. The treatment involved the application of a hyaluronic acid and collagenase ointment, followed by regular follow-up and data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvements in wound bed scores (WBS) were observed, with a reduction in healing times for all types of wounds. High patient satisfaction rates were reported, along with efficient debridement and notable pain reduction. Diabetic ulcers showed the most significant improvement in terms of healing time and WBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyaluronic acid and collagenase ointment demonstrated promising results in the treatment of chronic wounds. This treatment may offer a valuable addition to current wound care practices, particularly in challenging cases such as diabetic ulcers. More research is recommended, including randomized controlled trials, to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346241243102","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:03:29Z","timestamp":1713326609000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Hyaluronic Acid\/Collagenase Ointment in the Treatment of Chronic Wounds: A Retrospective Observational Study"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-128X","authenticated-orcid":false,"given":"Abdulkadir","family":"Calavul","sequence":"first","affiliation":[{"name":"Plastic Surgery Department, Sanl\u0131urfa Metrolife Hospital, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2022.0059"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.05.010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-015-0091-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/0113894501260002231101080505"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5152\/j.aott.2023.22163"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irac080"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000990"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517717261"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.5.312"},{"key":"e_1_3_3_11_2","first-page":"57","volume-title":"Endotext","author":"Boulton AJM.","year":"2023","unstructured":"Boulton AJM. The Diabetic Foot. In: Blackman MR ed.,Endotext. MDText.com, Inc.; July 28, 2023:57-58."},{"issue":"6","key":"e_1_3_3_12_2","first-page":"1421","article-title":"Enzymatic debridement: Is HA-collagenase the right synergy? Randomized double-blind controlled clinical trial in venous leg ulcers","volume":"21","author":"Scalise A","year":"2017","unstructured":"Scalise A, Campitiello F, Della Corte A, et al. Enzymatic debridement: Is HA-collagenase the right synergy? Randomized double-blind controlled clinical trial in venous leg ulcers. Eur Rev Med Pharmacol Sci. 2017;21(6):1421-1431.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13681"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102252"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800852"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102876"},{"issue":"40","key":"e_1_3_3_17_2","first-page":"48","article-title":"Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update)","volume":"40","author":"Chen P","year":"2023","unstructured":"Chen P, Vilorio NC, Dhatariya K, et al. Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 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