{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:51Z","timestamp":1791389511684,"version":"4.3.3"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    The aim of the present study was to evaluate effects of curcumin-polyethylene glycol loaded on chitosan-gelatin nanoparticles (C-PEG-CGNPs) on healing of methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA)-infected wounds in rat as a model study. Forty male Wistar rats were randomized into 5 groups of 8 animals each. In CNTRL group, no infected\/no treated wounds were covered with sterile saline 0.9% solution (0.1\u2005mL). In MRSA group, MRSA-infected wounds were only treated with sterile saline 0.9% solution (0.1\u2005mL). In MRSA\/CP group, 0.1\u2005mL curcumin nanoparticles (1 mg\/mL) was applied topically to treat MRSA-infected wounds. In MRSA\/CG group, 0.1\u2005mL CG (1 mg\/mL) was applied topically to treat MRSA-infected wounds. In MRSA\/CP-CG group, 0.1\u2005mL CP-CG (1 mg\/mL) was applied topically to treat MRSA-infected wounds. Microbiological examination; planimetric, biochemical, histological, morphometric studies, angiogenesis, hydroxyproline levels, and reverse transcription polymerase chain reaction for caspase 3, Bcl-2, and p53 showed significant difference between rats in MRSA\/CP-CG group in comparison with other groups (\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    &lt;\u2009.05). Accelerated and improved healing in wounds infected with MRSA were observed in animals treated with C-PEG-CGNPs. Via increasing solubility of curcumin in C-PEG-CGNP, this harmless and easily available composition could be considered to be topically applied in infected wounds.\n                  <\/jats:p>","DOI":"10.1177\/15347346241251734","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T01:14:40Z","timestamp":1715908480000},"page":"550-561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin-Polyethylene Glycol Loaded on Chitosan-Gelatin Nanoparticles Enhances Infected Wound Healing"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-1428","authenticated-orcid":false,"given":"Tara","family":"Kardan","sequence":"first","affiliation":[{"name":"Urmia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-9829","authenticated-orcid":false,"given":"Rahim","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Urmia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tukmechi","sequence":"additional","affiliation":[{"name":"Urmia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Urmia University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002411"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3777"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01193-19"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.11372"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2741\/e827"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.044"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10030074"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00264-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1081\/PFC-120027437"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119636"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-00235-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.04.020"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201033489748"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.08.056"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36806"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.11.017"},{"issue":"3","key":"e_1_3_2_19_2","first-page":"659","article-title":"Improvement of curcumin solubility by polyethylene glycol\/chitosan-gelatin nanoparticles (CUR-PEG\/CS-G-nps)","volume":"27","author":"Farnia P","year":"2016","unstructured":"Farnia P, Mollaei S, Bahrami A, Ghassempour A, Velayati AA, Ghanavi XX. Improvement of curcumin solubility by polyethylene glycol\/chitosan-gelatin nanoparticles (CUR-PEG\/CS-G-nps). Biomed Res. 2016;27(3):659-665.","journal-title":"Biomed Res"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp109370q"},{"issue":"10","key":"e_1_3_2_21_2","first-page":"1043","article-title":"Evaluation of antibiotic activity of methicillin in healing of full-thickness infected wounds with sensitized methicillin resistant Staphylococcus aureus in the presence of HAMLET","volume":"21","author":"Amniattalab A","year":"2018","unstructured":"Amniattalab A, Mohammadi R. Evaluation of antibiotic activity of methicillin in healing of full-thickness infected wounds with sensitized methicillin resistant Staphylococcus aureus in the presence of HAMLET. 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