{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:00:38Z","timestamp":1787162438739,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    The aim of the current study was to evaluate the outcomes of patients with diabetic foot osteomyelitis (DFO), comparing subjects with and without peripheral arterial disease (PAD). The study is a prospective study including a population of patients affected by a DFO located in the forefoot. All patients were managed by a surgical conservative approach defined by the removal of the infected bone, in association with the antibiotic therapy. Patients were divided into two groups: those with PAD (neuro-ischaemic DFO) and those without (neuropathic DFO). After 1 year of follow-up, the following outcome were evaluated and compared between groups: healing, healing time, minor amputation, major amputation, hospitalization, need for surgical re-intervention. Overall, 166 patients were included, 87(52.4%) of them had neuro-ischaemic DFO and 79 (47.6%) neuropathic DFO. Patients with neuro-ischaemic DFO in comparison to neuropathic DFO were older (72.5\u2009\u00b1\u20099 vs 64.1\u2009\u00b1\u200915.5 years,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.0001), had longer diabetes duration (21.8\u2009\u00b1\u20095.6 vs 16.4\u2009\u00b1\u20097.6 years,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.0001), higher rate of dialysis (13.8 vs 1.3%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.001) and ischaemic heart disease (79.3 vs 12.7%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.0001). Outcomes for neuro-ischaemic DFO and neuropathic DFO were: healing (96.5 vs 97.5%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.7), healing time (7.8\u2009\u00b1\u20096.2 vs 5.7\u2009\u00b1\u20093.7 weeks,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.01), minor amputation (16.1 vs 3.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.006), major amputation (0 vs 0%, ns), hospitalization (90.8 vs 51.9%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.0001), surgical re-intervention (14.9 vs 8.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.004) respectively. In addition, PAD resulted in an independent predictor of minor amputation, hospitalization, and surgical re-intervention. DFO in patients with PAD was characterized by longer healing time, more cases of minor amputation, hospitalization, and surgical re-intervention. PAD independently predicted the risk of minor amputation, hospitalization, and surgical re-intervention, while it was not associated with the healing rate.\n                  <\/jats:p>","DOI":"10.1177\/15347346241264383","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T21:26:46Z","timestamp":1721597206000},"page":"726-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Diabetic Foot Osteomyelitis in Patients with and without Peripheral Arterial Disease: Two Different Diseases?"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-9622","authenticated-orcid":false,"given":"Marco","family":"Meloni","sequence":"first","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Bellizzi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Andreadi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Di Venanzio","sequence":"additional","affiliation":[{"name":"Studio Podologico Di Venanzio, Rieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giurato","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Bellia","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Uccioli","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lauro","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"},{"name":"University Hospital Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3747"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1799"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/511036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4312737"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2014.06.011"},{"key":"e_1_3_3_8_2","first-page":"153473462312077","article-title":"Hospital readmission in patients with diabetic foot ulcers: prevalence, causes, and outcomes","author":"Meloni M","year":"2023","unstructured":"Meloni M, Andreadi A, Ruotolo V, et al. Hospital readmission in patients with diabetic foot ulcers: prevalence, causes, and outcomes. Int J Low Extrem Wounds. 2023:15347346231207747. doi: https:\/\/doi.org\/10.1177\/15347346231207747. Epub ahead of print. PMID: 37849322.","journal-title":"Int J Low Extrem Wounds"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13537"},{"issue":"1","key":"e_1_3_3_10_2","article-title":"Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"Lipsky BA","year":"2020","unstructured":"Lipsky BA, Senneville \u00c9, Abbas ZG, et al.. Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(Suppl 1):e3280. doi: https:\/\/doi.org\/10.1002\/dmrr.3280. PMID: 32176444.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/10711007221088552"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i4.135"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061780"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03192.x"},{"issue":"6","key":"e_1_3_3_16_2","first-page":"1325","article-title":"Diabetic foot ulcers: prevention, diagnosis and classification","volume":"57","author":"Armstrong DG","year":"1998","unstructured":"Armstrong DG, Lavery LA. Diabetic foot ulcers: prevention, diagnosis and classification. Am Fam Physician. 1998;57(6):1325-1332, 1337-8. PMID: 9531915","journal-title":"Am Fam Physician"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3690"},{"issue":"1","key":"e_1_3_3_18_2","article-title":"Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update)","volume":"36","author":"Schaper NC","year":"2020","unstructured":"Schaper NC, van Netten JJ, Apelqvist J, et al. Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(Suppl 1):e3266. doi: https:\/\/doi.org\/10.1002\/dmrr.3266. PMID: 32176447.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz486"},{"issue":"1","key":"e_1_3_3_20_2","article-title":"Guidelines on the classification of diabetic foot ulcers (IWGDF 2019)","volume":"36","author":"Monteiro-Soares M","year":"2020","unstructured":"Monteiro-Soares M, Russell D, Boyko EJ, et al.. Guidelines on the classification of diabetic foot ulcers (IWGDF 2019). Diabetes Metab Res Rev. 2020;36(Suppl 1):e3273. doi: https:\/\/doi.org\/10.1002\/dmrr.3273. PMID: 32176445.","journal-title":"Diabetes Metab Res Rev"},{"issue":"1","key":"e_1_3_3_21_2","article-title":"Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update)","volume":"36","author":"Hinchliffe RJ","year":"2020","unstructured":"Hinchliffe RJ, Forsythe RO, Apelqvist J, et al.. Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(Suppl 1):e3276. doi: https:\/\/doi.org\/10.1002\/dmrr.3276. Epub 2020 Jan 20. PMID: 31958217.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346231178642"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613502033"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1526"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.7547\/18-185"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03528.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0976-1"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1131-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000164172.28918.3f"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90476-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90894-1"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/107110070602701003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0831"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1223"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13680"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05278-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.02.006"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2400"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619884438"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241264383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346241264383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241264383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:50:13Z","timestamp":1786103413000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346241264383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/15347346241264383"],"URL":"https:\/\/doi.org\/10.1177\/15347346241264383","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}