{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:30:28Z","timestamp":1793727028249,"version":"4.6.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023RC142"],"award-info":[{"award-number":["2023RC142"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"crossref","award":["LGF20H060004"],"award-info":[{"award-number":["LGF20H060004"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aim to evaluate the efficacy of local antibiotic delivery systems in patients with diabetic foot osteomyelitis (DFO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Web of Science, PubMed, and Embase databases were searched for relevant publications until March 2024. All studies evaluating the efficacy of local antibiotic delivery systems in patients with DFO were included. We calculated pooled risk ratio (RR) with 95% CIs for binary outcomes and mean difference (MD) for continuous outcomes. The Cochrane's risk of bias tool and methodological index for non-randomized studies (MINORS) assessment were used to evaluate the quality of studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 9 studies with 491 patients were included in this analysis. The overall healing rate in antibiotic group was 0.85 (95% CI: 0.67, 0.97). Healing rates were significantly higher in the antibiotic group compared to the control group (RR: 1.18, 95% CI: 1.01, 1.38). Furthermore, recurrence rates and amputation rates have no significantly difference between the antibiotic group and the control group (RR: 0.30, 95% CI: 0.04, 2.12 and RR: 0.22, 95% CI:0.03, 1.91), along with no significantly difference in healing time and hospital stays(MD: \u22127.87, 95% CI: \u221220.81, 5.07 and MD:\u22122.33, 95% CI:\u22125.17, 0.50). No obvious publication bias was observed in the funnel plot (Egger's test,\n                      <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                      =\u2009.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta-analysis found that diabetic foot osteomyelitis patients treated with local antibiotic delivery systems had better healing rates than the control group. However, no significant differences were found in healing time, recurrence, hospital stays, or amputation rates. Larger randomized controlled trials are necessary in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346241266062","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T07:11:16Z","timestamp":1721545876000},"page":"379-388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Efficacy of Local Antibiotic Delivery Systems Therapy in the Management of Diabetic Foot Osteomyelitis: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"25","author":[{"given":"Di","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Orthopedic Trauma, Zhuji People's Hospital of Zhejiang Province, Zhuji, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaofeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gouping","family":"Ma","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6990-7737","authenticated-orcid":false,"given":"Liqing","family":"Ding","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216701"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.06.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716664364"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-018-0256-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.09.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000530"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57040339"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12418"},{"issue":"11","key":"e_1_3_2_11_2","first-page":"511","article-title":"Depot effects of various antibiotics mixed with Palacos resins","volume":"41","author":"Buchholz HW","year":"1970","unstructured":"Buchholz HW, Engelbrecht H. 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