{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:26:30Z","timestamp":1793726790851,"version":"4.6.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009006","name":"Integra LifeSciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    To compare the incidence of infection, wound closure and time to wound closure in patients treated with cryopreserved (CPUT) and lyopreserved umbilical tissue (LPUT) in complex diabetic surgical wounds. This single-blinded 12-week randomized clinical trial compared cryopreserved and lyopreserved amniotic cord tissue to treat complex diabetic foot wounds. LPUT or CRAT was applied at baseline and again after four weeks. We enrolled subjects with UT2A-D and 3A-D wounds (depth to tendon, muscle, or bone with infection and\/or PAD) and excluded subjects with ABI\u2009&lt;\u20090.5 or TBI\u2009&lt;\u20090.3, untreated osteomyelitis, and autoimmune diseases. We used a 3-D camera to evaluate wound area and volume. The mean baseline wound areas were 12.9\u2009\u00b1\u200910.7\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    for CPUT and 11.7\u2009\u00b1\u20097.0\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    for LPUT. The mean baseline wound volume was 7.5\u2009\u00b1\u20098.1 for CPUT and 9.2\u2009\u00b1\u200910.2\u2005cm\n                    <jats:sup>3<\/jats:sup>\n                    for LPUT. There was no difference between CPUT and LPUT in wound closure (36.8% vs 19.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.21) or infection (10.5% vs 4.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.60). There was no difference in mean wound area reduction between CPUT and LPUT (75.9\u2009\u00b1\u200932.3% vs 65.5\u2009\u00b1\u200938.4%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.41), nor in mean volume reduction (85.0\u2009\u00b1\u200930.8% vs 79.9\u2009\u00b1\u200931.9%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.61). In addition, there was no difference in wound closure trajectories for changes in area (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.75) or volume (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.43). Cryopreserved and lyopreserved amniotic tissue provided similar results in patients with complex diabetic foot wounds.\n                  <\/jats:p>","DOI":"10.1177\/15347346241273282","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T08:19:46Z","timestamp":1733386786000},"page":"852-860","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomized Clinical Trial to Compare Cryopreserved and Lyopreserved Umbilical Cord Tissue to Treat Complex Diabetic Foot Wounds"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-9952","authenticated-orcid":false,"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0909","authenticated-orcid":false,"given":"Mehmet A.","family":"Suludere","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Killeen","sequence":"additional","affiliation":[{"name":"University of Texas Rio Grande Valley School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Raspovic","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-9235","authenticated-orcid":false,"given":"Peter A.","family":"Crisologo","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-6283","authenticated-orcid":false,"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12329"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12649"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204060"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13479"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.06.002"},{"issue":"1","key":"e_1_3_2_7_2","article-title":"2. Classification and diagnosis of diabetes: standards of care in diabetes-2023","volume":"46","author":"ElSayed NA","year":"2023","unstructured":"ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and diagnosis of diabetes: standards of care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S19-S40.","journal-title":"Diabetes Care"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.855"},{"issue":"1","key":"e_1_3_2_9_2","article-title":"Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"Lipsky BA","year":"2020","unstructured":"Lipsky BA, Senneville \u00c9, Abbas ZG, et al. Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(Suppl 1):e3280.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12328"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3604203"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.02.044"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12741"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026345"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-017-0461-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-022-00575-y"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-021-01084-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz489"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13310-6"},{"issue":"2","key":"e_1_3_2_23_2","first-page":"23","article-title":"Human cryopreserved viable amniotic membrane inhibits the growth of bacteria associated with chronic wounds","volume":"8","author":"Mao Y","year":"2016","unstructured":"Mao Y, Hoffman T, Johnson A, Duan-Arnold Y, Danilkovitch A, Kohn J. Human cryopreserved viable amniotic membrane inhibits the growth of bacteria associated with chronic wounds. The Journal of Diabetic Foot Complications. 2016;8(2, No. 1):23-30.","journal-title":"The Journal of Diabetic Foot Complications"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241273282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346241273282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241273282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:47:43Z","timestamp":1786103263000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346241273282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/15347346241273282"],"URL":"https:\/\/doi.org\/10.1177\/15347346241273282","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]}}}