{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:26:28Z","timestamp":1793726788002,"version":"4.6.1"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Integra Life Science","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Our objective was to compare clinical outcomes in diabetic foot ulcers (DFU) treated with AmnioExcel\n                    <jats:sup>\u00ae<\/jats:sup>\n                    applied weekly (AMX1) or biweekly (AMX2) over a 12-week evaluation period. This randomized clinical trial evaluated 40 people with UT 1A and 1D DFUs &gt;30 days but less than 6 months duration and age &gt;21 years. We excluded patients with untreated osteomyelitis, gangrene, widespread malignancy, or active substance abuse. Patients received amniotic tissue either once a week or every other week. We used a 3D measurement device (inSight, eKare, Fairfax, Virginia)\u201d. There was no difference in the incidence of healing (AMX1 30.0% vs AMX2 50.0%, p\u2009=\u20090.20), time to heal (69.3\u2009\u00b1\u200930.3 vs 45.8\u2009\u00b1\u200925.6 days, p\u2009=\u20090.15), or incidence of infection (AMX1 35.0% vs AMX2 25.0%, p\u2009=\u20090.49). The mean wound area reduction was 0.18\u2009\u00b1\u20090.48\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    per week for AMX1 and 0.15\u2009\u00b1\u20090.63\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    week for AMX2 (p\u2009=\u20090.42). When we compared wound healing trajectories in healers and non-healers. There were no differences in the mean wound area reduction for healers (0.26\u2009\u00b1\u20090.40\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    per week) and non-healers (0.14\u2009\u00b1\u20090.52\u2005cm\n                    <jats:sup>2<\/jats:sup>\n                    per week, p\u2009=\u20090.20). Our results suggested there is no difference in the incidence of healing, time to heal or incidence of infection based on weekly or biweekly application of amniotic tissue.\n                  <\/jats:p>","DOI":"10.1177\/15347346241276697","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T08:08:27Z","timestamp":1736410107000},"page":"891-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized Controlled Trial to Compare AmnioExcel Human Amniotic Allograft in Weekly Versus Biweekly Treatment of Diabetic Foot Ulcers"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-9952","authenticated-orcid":false,"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0909","authenticated-orcid":false,"given":"Mehmet A.","family":"Suludere","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Raspovic","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-9235","authenticated-orcid":false,"given":"Peter Andrew","family":"Crisologo","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(97)00163-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1995.tb02079.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8227(97)00058-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-022-00575-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.1.84"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12328"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-8422(23)01030-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3280"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.02.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12097"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.7.347"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.4.350"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12357"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup7.S18"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000222891.74489.33"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1300"}],"container-title":["The 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