{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:47Z","timestamp":1777712387349,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    No consensus or guideline has been established regarding the optimal timing of tissue resection after revascularization in patients with chronic limb-threatening ischemia (CLTI). This study aimed to compare early tissue resection and watchful waiting after revascularization regarding the outcomes of patients with CLTI. We searched PubMed, the Cochrane Library, and EMBASE for relevant randomized trials and observational studies published from their inception to May 1, 2024. In total, five articles were analyzed. The results showed that the early tissue resection group had a higher wound healing rate than the watchful waiting group (I\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u200926%, odds ratio [OR]\u2009=\u20092.80, 95% confidence interval [CI] 1.32 to 5.92,\n                    <jats:italic>P\u2009<\/jats:italic>\n                    =\u20090.007). However, the rate of major amputation was significantly higher in the early tissue resection group than in the watchful waiting group (I\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u20095%, OR = 1.48, 95% CI 1.18 to 1.86,\n                    <jats:italic>P\u2009<\/jats:italic>\n                    &lt;\u20090.001), and wound recurrence rate in the early tissue resection group was relatively higher than that in the watchful waiting group (I\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u20090%, OR = 2.42, 95% CI: 0.99 to 5.93,\n                    <jats:italic>P\u2009<\/jats:italic>\n                    =\u20090.05). No statistical significance was found in the rate of postoperative mortality (I\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u20092%, OR = 0.99, 95% CI: 0.69 to 1.41,\n                    <jats:italic>P\u2009<\/jats:italic>\n                    =\u20090.94) and wound healing time (I\n                    <jats:sup>2\u2009<\/jats:sup>\n                    =\u200997%, standardized mean difference\u2009=\u2009-105.92, 95% CI \u2212232.96 to 21.13,\n                    <jats:italic>P\u2009<\/jats:italic>\n                    =\u20090.10) between the early tissue resection and watchful waiting groups. For patients without signs of infection, a watchful waiting strategy could reduce the risk of major amputation.\n                  <\/jats:p>","DOI":"10.1177\/15347346241279517","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T10:56:25Z","timestamp":1724842585000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Tissue Resection Versus Watchful Waiting After Revascularization for Chronic Limb-Threatening Ischemia: A Meta-Analysis"],"prefix":"10.1177","volume":"24","author":[{"given":"Xu","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-5199","authenticated-orcid":false,"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1709326"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.07.065"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002938"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.10.036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.02.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/17085381211067601"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_3_9_2","first-page":"170853812312148","article-title":"Minor amputation after revascularization in chronic limb-threatening ischemia: What is the optimal timing?","author":"Tanda E","year":"2023","unstructured":"Tanda E, Ruiu G, Casula M, et al. Minor amputation after revascularization in chronic limb-threatening ischemia: What is the optimal timing? Vascular. 2023;32:17085381231214819.","journal-title":"Vascular"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010273"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319720958554"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.21-00136"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2023.11.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033898"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065277"},{"issue":"24","key":"e_1_3_3_17_2","article-title":"Infra-inguinal bypass surgery vs endovascular revascularization for chronic limb-threatening ischemia in average- and high-risk patients","volume":"0741","author":"Morisaki K","year":"2024","unstructured":"Morisaki K, Matsuda D, Guntani A, et al. Infra-inguinal bypass surgery vs endovascular revascularization for chronic limb-threatening ischemia in average- and high-risk patients. J Vasc Surg. 2024;S0741-5214(24):00505-6.","journal-title":"J Vasc Surg"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.11.039"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.11.023"},{"issue":"24","key":"e_1_3_3_20_2","first-page":"01099\u20131","article-title":"Real world application of WIfI scores in peripheral arterial disease patients","volume":"0741","author":"Smith ME","year":"2024","unstructured":"Smith ME, Braet DJ, Albright J, Corriere MA, Osborne NH, Henke P. Real world application of WIfI scores in peripheral arterial disease patients. J Vasc Surg. 2024;S0741-5214(24):01099\u20131.","journal-title":"J Vasc Surg"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/17085381221102801"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2024_91-106"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.57653"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.888809"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.05.025"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2021.08.001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000105"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000091"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-018-0523-z"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241279517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346241279517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346241279517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:14Z","timestamp":1777457114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346241279517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/15347346241279517"],"URL":"https:\/\/doi.org\/10.1177\/15347346241279517","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]}}}