{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:10:12Z","timestamp":1786122612196,"version":"build-2736575974"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The current study was aimed to evaluate the potential of\n                      <jats:italic toggle=\"yes\">Moringa oleifera<\/jats:italic>\n                      against diabetic foot ulcer, where the wound healing is impaired and susceptible to infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The effects of\n                      <jats:italic toggle=\"yes\">M. oleifera<\/jats:italic>\n                      hydroalcoholic bark extract (MOHE) on different parameters influencing diabetic wound healing were comprehensively investigated including: anti-inflammatory effects, antibacterial properties, antioxidant activity, anti-diabetic properties, and fibroblast proliferation and migration. Furthermore, in vivo studies were conducted in diabetic rats and Zebrafish to investigate the topical effects of MOHE on wound healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings of this study demonstrated that MOHE has strong anti-diabetic effect, including a significant inhibition of \u03b1-amylase activity (IC50\u2009=\u20090.043\u2005mg\/mL) and 2.92-fold increase in 2-NBDG uptake in McCoy cells. MOHE demonstrated considerable antioxidant activity, inhibiting DPPH (IC50: 0.046\u2005mg\/mL) and ABTS (IC50: 0.04\u2005mg\/mL) free radicals. In\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      wound healing studies employing MOHE revealed a significant increase in McCoy fibroblast proliferation (148.83%) and improved migration, resulting in a wound closure rate of 46.3%. MOHE exhibited significant antibacterial activity against pathogenic bacteria species. It efficiently reduced heat-induced RBC hemolysis, with anti-inflammatory effect of 73% at 0.2\u2005mg\/mL. Furthermore, MOHE demonstrated better results in the treatment of diabetic wounds in Wistar rats and fin regeneration in Zebra fish compared to Calendula cream.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This evidence based pharmacological study highlights the promising potential of MOHE in facilitating the healing of diabetic wounds, offering a topical approach to address this challenging healthcare issue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346241297829","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T09:01:07Z","timestamp":1733389267000},"page":"835-851","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of\n                    <i>Moringa oleifera<\/i>\n                    Hydro-Alcoholic Bark Extract on Diabetic Wound Healing: A Topical Approach"],"prefix":"10.1177","volume":"25","author":[{"given":"Diksha","family":"Manhas","sequence":"first","affiliation":[{"name":"Jaypee University of Information Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-1070","authenticated-orcid":false,"given":"Udayabanu","family":"Malairaman","sequence":"additional","affiliation":[{"name":"Jaypee University of Information Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"IDF Diabetes Atlas, tenth","author":"Federation ID","year":"2021","unstructured":"Federation ID. 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