{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:11:00Z","timestamp":1786122660633,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai Municipal Health Commission Clinical Key Specialty Construction Project","award":["shslczdzk03801"],"award-info":[{"award-number":["shslczdzk03801"]}]},{"name":"Shanghai Chinese and Western Medicine Clinical Cooperation Pilot Construction Project","award":["ZY (2018-2020) - FWTX - 1103"],"award-info":[{"award-number":["ZY (2018-2020) - FWTX - 1103"]}]},{"name":"Shanghai Municipal Health Commission Haipai Traditional Chinese Medicine School Inheritance and Innovation Team Construction Project","award":["2021LPTD-001"],"award-info":[{"award-number":["2021LPTD-001"]}]},{"name":"Three year Action Plan Project of Shanghai Shenkang Hospital Development Center","award":["16CR1025B"],"award-info":[{"award-number":["16CR1025B"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774317"],"award-info":[{"award-number":["81774317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Clinical Key Specialty Construction Project","award":["shslczdzk03801"],"award-info":[{"award-number":["shslczdzk03801"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with diabetes mellitus (DM) face a higher risk of developing chronic refractory wounds. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and epidermal growth factor receptor (EGFR) plays an important role in diabetes-related complications. This study aims to analyze the correlation between the 3 indicators and diabetic chronic refractory wounds, in order to establish the diagnostic value of these 3 indicators and provide reference for the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We selected 168 patients, with 84 in healing group and 84 in refractory group. The levels of serum VEGF, bFGF, and wound tissue EGFR were compared before treatment, and the correlation between the 3 indicators and the refractory wounds was analyzed. After the specific treatment in refractory group, the clinical efficacy and wound closure index was recorded, and the correlation between them and the 3 indicators were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 3 indicators were all protective factors for diabetic chronic refractory wounds (\n                      <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                      &lt;\u2009.05). The serum VEGF and bFGF had relatively low diagnostic value for diabetic chronic refractory wounds, while wound tissue EGFR demonstrated higher diagnostic value (\n                      <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                      &lt;\u2009.05). The 3 indicators had a positive correlation with both the clinical efficacy and the wound closure index (\n                      <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                      &lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher levels of serum VEGF, bFGF, and wound tissue EGFR are conducive to reducing the incidence of diabetic chronic refractory wounds. The combined measurement of these indicators holds high diagnostic value for the disease. Moreover, the higher the expression levels of these 3 indicators, the more favorable the clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346241313010","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:10:48Z","timestamp":1737108648000},"page":"907-915","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Significance of Serum VEGF, bFGF, and Wound Tissue EGFR in Diabetic Chronic Refractory Wounds"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-793X","authenticated-orcid":false,"given":"Xuanyu","family":"Wang","sequence":"first","affiliation":[{"name":"Longhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafa","family":"Que","sequence":"additional","affiliation":[{"name":"Longhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000454919"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12945"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.646967"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2021.2002235"},{"issue":"2","key":"e_1_3_4_6_2","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis","volume":"59","author":"Melincovici CS","year":"2018","unstructured":"Melincovici CS, Bo\u015fca AB, \u015eu\u015fman S, et al. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. 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