{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:01:05Z","timestamp":1777712465212,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Venous leg ulcers (VLUs) cause a significant health care burden due to high health care costs, prolonged treatment, and high recurrence. Our study aims to compare between retrograde venous perfusion (RVP) combined with conventional therapy versus conventional therapy for treatment of chronic VLUs with regard to safety and efficacy. Drugs used for RVP were prostaglandin E1 (alprostadil), calcium heparin, hydrocortisone, pheniramine maleate, and lidocaine. This was a randomized controlled study conducted on 60 patients with chronic VLUs from June 2023 to June 2024. Patients were divided into two groups: RVP with conventional therapy versus conventional therapy only. Outcomes included the rate of complete ulcer closure and the percentage of healing at 6 months, ulcer-related complications, and recurrence rates. At 6 months, the RVP with conventional therapy group had a significantly higher ulcer surface area reduction, 83.7% versus 61%, p\u2009=\u20090.001, and a higher percentage of complete healing, 86.2% versus 44.8%, p\u2009=\u20090.005, as compared to the conventional therapy alone group. Similarly, time to complete healing was shorter in the RVP group at 7.8\u2009\u00b1\u20092.61 weeks versus 10.7\u2009\u00b1\u20094.31 weeks, p\u2009&lt;\u20090.001. There was no significant difference in rates of wound infection between the two groups. Lower, though statistically non-significant, recurrence rates were seen within the RVP group: 8% versus 15.4%. RVP should be considered one of the adjunctive treatments for chronic VLUs. It offered positive results with regard to improved healing outcomes and reduced ulcer size. More researches are needed to confirm these conclusions.<\/jats:p>","DOI":"10.1177\/15347346251323828","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:42:27Z","timestamp":1741887747000},"page":"630-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrograde Venous Perfusion Augments Healing of Chronic Venous Leg Ulcers: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Hesham F.","family":"El Morshedy","sequence":"first","affiliation":[{"name":"Vascular &amp; Endovascular Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Vascular &amp; Endovascular Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam M.","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Vascular &amp; Endovascular Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr M.","family":"El-Mahallawy","sequence":"additional","affiliation":[{"name":"Vascular &amp; Endovascular Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama H.","family":"Abd Raboh","sequence":"additional","affiliation":[{"name":"General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-018X","authenticated-orcid":false,"given":"Ahmed H.","family":"El-Barbary","sequence":"additional","affiliation":[{"name":"Vascular &amp; Endovascular Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196153"},{"key":"e_1_3_2_3_2","volume-title":"Venous Leg Ulceration. Wound Healing-New insights into Ancient Challenges","author":"\u00c7erman AA","year":"2016","unstructured":"\u00c7erman AA, Altunay \u0130K, Karabay EA. Venous Leg Ulceration. Wound Healing-New insights into Ancient Challenges. IntechOpen; 2016."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010029"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01058.x"},{"issue":"1","key":"e_1_3_2_6_2","first-page":"204","article-title":"Uber einen neuen Weg Localan\u00e4 sthesie an den Gliedemaassen zu erzeugen","volume":"37","author":"Bier A","year":"1908","unstructured":"Bier A. Uber einen neuen Weg Localan\u00e4 sthesie an den Gliedemaassen zu erzeugen. Verh Dtsch Ges Chirurgie. 1908;37:204-213. quoted from Brill S, Middleton W, Brill G, Fisher A. Bier's block; 100 years old and still going strong!. Acta Anaesthesiologica Scandinavica. 2004;48(1):117-122.","journal-title":"Verh Dtsch Ges Chirurgie"},{"key":"e_1_3_2_7_2","volume-title":"Comparative study on Role of Retrograde Venous Perfusion Therapy and Systemic Antibiotic Therapy in Treatment of Diabetic Ulcer Foot in Government Rajaji Hospital, Madurai","author":"Gowthin D","year":"2020","unstructured":"Gowthin D. Comparative study on Role of Retrograde Venous Perfusion Therapy and Systemic Antibiotic Therapy in Treatment of Diabetic Ulcer Foot in Government Rajaji Hospital, Madurai. 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