{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:59:33Z","timestamp":1788343173451,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Ministry of Health of the Czech Republic","award":["NU20-01-00078"],"award-info":[{"award-number":["NU20-01-00078"]}]},{"name":"National Institute for Research of Metabolic and Cardiovascular Diseases project","award":["EXCELES, LX22NPO5104"],"award-info":[{"award-number":["EXCELES, LX22NPO5104"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    The aim of study was to confirm the hypothesis that advanced medial arterial calcification (MAC)\/ small artery disease (SAD), much like the progression of peripheral arterial disease (PAD) stages can adversely impact the outcomes in DFU patients, even after successful endovascular procedures. In retrospective study, we enrolled 54 patients with DFUs who underwent percutaneous transluminal angioplasty (PTA). MAC was quantified using a three-level scoring system based on radiographs. Patients were categorized based on their MAC score into three groups. Study groups were compared in terms of primary DFU outcomes (healing, amputations) and secondary DFU outcomes (mortality, changes in transcutaneous oxygen pressure (TcPO2)) three and six months after PTA. The MAC\/SAD score increased significantly with age (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    =\u20090.014). The MAC\/SAD score was't associated with the risk of amputation or the healing of DFUs up to three months after revascularization. However, a significant association was observed after six months (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    =\u20090.043). The MAC\/SAD score correlated significantly with severity of PAD, as classified by the Global Limb Anatomic Staging System (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    =\u20090.042) and the Graziani system (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    =\u20090.019). We found a negative correlation between the MAC\/SAD score and absolute levels of TcPO2 after PTA. MAC\/SAD score was significantly associated with long-term unhealed DFUs and the risk of lower limb amputations.\n                  <\/jats:p>","DOI":"10.1177\/15347346251323938","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:42:27Z","timestamp":1741887747000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Small Artery Disease as a Predictor of Wound Healing in Patients with Diabetic Foot After Revascularization"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-2690","authenticated-orcid":false,"given":"Radka","family":"Jarosikov\u00e1","sequence":"first","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"},{"name":"Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor","family":"Adla","sequence":"additional","affiliation":[{"name":"Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Turza","sequence":"additional","affiliation":[{"name":"Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Dubsky","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Woskov\u00e1","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Soj\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u011bra","family":"L\u00e1nsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Statistics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-5383","authenticated-orcid":false,"given":"Vladimira","family":"Fejfarov\u00e1","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"},{"name":"Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","article-title":"Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update)","volume":"40","author":"Bus SA","unstructured":"Bus SA, Sacco ICN, Monteiro-Soares M, et al. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3651. doi: https:\/\/doi.org\/10.1002\/dmrr.3651. Epub 2023 Jun 11. PMID: 37302121.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3648"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3686"},{"issue":"5","key":"e_1_3_2_5_2","first-page":"655","article-title":"BAD transmission and SAD distribution: A new scenario for critical limb ischemia","volume":"59","author":"Ferraresi R","unstructured":"Ferraresi R, Mauri G, Losurdo F, et al. BAD transmission and SAD distribution: A new scenario for critical limb ischemia. J Cardiovasc Surg (Torino). 2018 Oct;59(5):655-664. doi: https:\/\/doi.org\/10.23736\/S0021-9509.18.10572-6. Epub 2018 May 22. PMID: 29786411.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_2_6_2","unstructured":"Ferraresi R Ucci A Casini A Montero-Baker M. BAD and SAD-MAC: A New Scenario for CLTI American College of Cardiology 2021 Mar https:\/\/www.acc.org\/Latest-in-Cardiology\/Articles\/2021\/03\/04\/14\/34\/BAD-and-SAD-MAC."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602820966309"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2010.12.025"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2023.38.e160"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.978"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.11.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Conte MS Bradbury AW Kolh P et al.; GVG Writing Group for the Joint Guidelines of the Society for Vascular Surgery (SVS) European Society for Vascular Surgery (ESVS) and World Federation of Vascular Societies (WFVS). Global vascular guidelines on the management of chronic limb-threatening ischemia. Eur J Vasc Endovasc Surg. 2019 Jul;58(1S):S1-S109.e33. doi: https:\/\/doi.org\/10.1016\/j.ejvs.2019.05.006. Epub 2019 Jun 8. Erratum in: Eur J Vasc Endovasc Surg. 2020 Mar;59(3):492-493. doi: https:\/\/doi.org\/10.1016\/j.ejvs.2019.11.025. Erratum in: Eur J Vasc Endovasc Surg. 2020 Jul;60(1):158-159. doi: https:\/\/doi.org\/10.1016\/j.ejvs.2020.04.033. PMID: 31182334; PMCID: PMC8369495.","DOI":"10.1016\/j.ejvs.2020.04.033"},{"key":"e_1_3_2_13_2","article-title":"Medial arterial calcification: JACC state-of-the-art review","author":"Lanzer P","unstructured":"Lanzer P, Hannan FM, Lanzer JD, et al. Medial arterial calcification: JACC state-of-the-art review. J Am Coll Cardiol. 2021 Sep 14;78(11):1145-1165.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000454"},{"issue":"2","key":"e_1_3_2_15_2","first-page":"193","article-title":"Transcutaneous oxygen measurements in lower extremity ischemia: Effects of position, oxygen inhalation, and arterial reconstruction","volume":"103","author":"Moosa HH","unstructured":"Moosa HH, Peitzman AB, Makaroun MS, Webster MW, Steed DL. Transcutaneous oxygen measurements in lower extremity ischemia: Effects of position, oxygen inhalation, and arterial reconstruction. Surgery. 1988 Feb;103(2):193-198. PMID: 3340988.","journal-title":"Surgery"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.744195"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3276"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.02.014"},{"key":"e_1_3_2_20_2","article-title":"BASIL Trial Participants. Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: An intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy","author":"Bradbury AW","year":"2010","unstructured":"Bradbury AW, Adam DJ, Bell J, et al.; BASIL Trial Participants. Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: An intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy. J Vasc Surg. 2010 May;51(5 Suppl):5S-17S. doi: https:\/\/doi.org\/10.1016\/j.jvs.2010.01.073. Erratum in: J Vasc Surg. 2010 Dec;52(6):1751. Bhattachary, V [corrected to Bhattacharya, V]. PMID: 20435258.","journal-title":"J Vasc Surg"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-1114-2"},{"key":"e_1_3_2_22_2","article-title":"Performance of non-invasive bedside vascular testing in the prediction of wound healing or amputation among people with foot ulcers in diabetes: A systematic review","author":"Chuter V","unstructured":"Chuter V, Schaper N, Hinchliffe R, et al. Performance of non-invasive bedside vascular testing in the prediction of wound healing or amputation among people with foot ulcers in diabetes: A systematic review. Diabetes Metab Res Rev. 2024 Mar;40(3):e3701. doi: https:\/\/doi.org\/10.1002\/dmrr.3701. Epub 2023 Jul 26. PMID: 37493206.","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.07.009"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251323938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346251323938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251323938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:28Z","timestamp":1777457128000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346251323938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/15347346251323938"],"URL":"https:\/\/doi.org\/10.1177\/15347346251323938","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]}}}