{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:26:44Z","timestamp":1793572004105,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Pengcheng Talents-Medical Youth Reserve Talents","award":["XWRCHT20220004"],"award-info":[{"award-number":["XWRCHT20220004"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic foot osteomyelitis (DFO) is often difficult to detect in its early stages, making diagnosis challenging. This study is to investigate the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and DFO, while also evaluating the potential of Lp-PLA2 as an early diagnostic biomarker for DFO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 265 patients with type 2 diabetes complicated by diabetic foot infections were selected for the study. Participants were divided into the Non-DFO group (184 cases) and the DFO group (81 cases). Serum Lp-PLA2 levels were measured. Logistic regression analysis was utilized to identify risk factors associated with DFO. Receiver Operating Characteristic curve analysis was performed to assess the diagnostic value of Lp-PLA2 in patients with DFO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lp-PLA2 in the DFO group were significantly higher than those in the Non-DFO group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Lp-PLA2 (OR, 1.015 [95% CI, 1.011-1.019];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), lower extremity arterial disease (OR, 2.453 [95% CI, 1.147-5.247];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05), and ESR (OR, 1.042 [95% CI, 1.026-1.059];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) were the independent risk factors for DFO. Lp-PLA2 and ESR were shown to be associated with DFO, with their respective areas under the curve (AUC) being 0.787 and 0.683. The sensitivity and specificity of Lp-PLA2 were 65.4% and 82.6%, respectively, while those of ESR were 48.1% and 95.1%. Combined Lp-PLA2 and ESR showed the best diagnostic performance (AUC 0.858, sensitivity 79.0%, specificity 84.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a preliminary one, Lp-PLA2 demonstrates significant diagnostic value for DFO. The combination of Lp-PLA2 and ESR can significantly improve diagnostic accuracy of DFO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346251340757","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:29:25Z","timestamp":1750818565000},"page":"1240-1247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Higher Serum Levels of Lipoprotein-Associated Phospholipase A2 are Associated with Diabetic Foot Osteomyelitis"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-5456","authenticated-orcid":false,"given":"Haojie","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Xuzhou Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shucai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xuzhou Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houfa","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xuzhou Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xuzhou Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/590012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i4.135"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13174"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.04.01"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1938640020921572"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000480"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu060"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2018.12.010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.09.015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2023.102000"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180111110550"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.129"},{"issue":"21","key":"e_1_3_3_14_2","first-page":"10730","article-title":"The value of serum lipoprotein-associated phospholipase A2, ischemia-modified albumin, and cystatin C in predicting coronary heart disease risk: A single center retrospective cohort study","volume":"27","author":"Le QF","year":"2023","unstructured":"Le QF, Liu J, Chen L. The value of serum lipoprotein-associated phospholipase A2, ischemia-modified albumin, and cystatin C in predicting coronary heart disease risk: A single center retrospective cohort study. Eur Rev Med Pharmacol Sci. 2023;27(21):10730\u201310735.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15160"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.03.026"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2015.09.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.07.023"},{"issue":"10","key":"e_1_3_3_19_2","article-title":"Elevated serum levels of Lp-PLA2 and IL-18 are associated with progression of diabetic foot ulcers","volume":"66","author":"Chen T","year":"2020","unstructured":"Chen T, Yu J, Wang J, Chang Q, Qian C. Elevated serum levels of Lp-PLA2 and IL-18 are associated with progression of diabetic foot ulcers. 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