{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:26:44Z","timestamp":1793572004088,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Rugao Science and Technology Bureau","award":["No. SRGS (23)077"],"award-info":[{"award-number":["No. SRGS (23)077"]}]},{"name":"Nantong Traditional Chinese Medicine Medical Alliance Project","award":["TZYK202212"],"award-info":[{"award-number":["TZYK202212"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To investigate the efficacy and mechanism of pig's toenail egg yolk ointment in treating pressure ulcers.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Eighty patients with Stage III-IV pressure ulcers were randomized into an experimental group (n\u2009=\u200950) receiving pig's toenail egg yolk ointment and a control group (n\u2009=\u200930) receiving conventional dressing. Clinical outcomes included Pressure Ulcer Scale for Healing(PUSH) score, wound healing rate, healing rate, and dressing costs. Additionally, a rat pressure ulcer model was used to assess healing rates, histopathology, and expression of VEGF, TNF-\u03b1, IL-1\u03b2, PI3 K, p-PI3 K, AKT, and p-AKT.\n                    <jats:bold>Results:<\/jats:bold>\n                    Clinical research: The experimental group showed significantly lower PUSH scores, higher wound healing rates, and reduced dressing costs compared to the control group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Animal experiments: In rats, the ointment group demonstrated faster wound healing, neovascularization, and reduced inflammatory cell infiltration. ELISA results showed increased VEGF and decreased TNF-\u03b1 and IL-1\u03b2 levels. Western blot analysis indicated elevated p-PI3 K and p-AKT expression in the ointment group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Pig's toenail egg yolk ointment promotes pressure ulcer healing by enhancing angiogenesis and modulating inflammatory factors through activation of the PI3K-Akt pathway.\n                  <\/jats:p>","DOI":"10.1177\/15347346251348798","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:29:25Z","timestamp":1750818565000},"page":"1290-1300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pig's Toenail Egg Yolk Ointment Promotes Pressure Ulcer Healing via the PI3K-Akt Pathway: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"25","author":[{"given":"Jiansheng","family":"Shao","sequence":"first","affiliation":[{"name":"Anorectal Department, Rugao Hospital of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4731-8303","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anorectal Department, Rugao Hospital of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiamei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anorectal Department, Rugao Hospital of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Nursing Department, Rugao Bo'ai Hospital, Rugao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Gu","sequence":"additional","affiliation":[{"name":"Anorectal Department, Rudong County Hospital of Traditional Chinese Medicine, Rudong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Anorectal Department, Rugao Hospital of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2006.12.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081918"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000281"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2024.05.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2024.0197"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003366"},{"key":"e_1_3_2_8_2","first-page":";38(2):101133","article-title":"Prophylactic dressings for preventing sacral pressure injuries in adult intensive care unit patients: A randomised feasibility trial","author":"Latimer S","year":"2025","unstructured":"Latimer S, Chaboyer W, Walker RM, Thalib L, Deakin JL, Gillespie BM. 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