{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:26:37Z","timestamp":1793571997369,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["140111189886"],"award-info":[{"award-number":["140111189886"]}],"id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pressure ulcers seriously affect patient quality of life. The present study aimed to investigate the therapeutic effects of 25% zinc oxide topical cream on treating stage I and II pressure ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, double-blind clinical trial involved 60 patients, divided into the control group (n\u2009=\u200930) receiving a silver-containing dressing and the intervention group (n\u2009=\u200930) treated with 25% zinc oxide cream. Wound assessments were conducted on days 0, 7, and 14, alongside standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the end, the intervention group showed significantly higher rates of \u201cpartial healing\u201d and \u201cperi-wound erythema reduction\u201d than the control group (\n                      <jats:italic toggle=\"yes\">\n                        p\n                        <jats:sub>value<\/jats:sub>\n                      <\/jats:italic>\n                      \u2009&lt;\u2009.05). The intervention group's partial healing increased from 3.33% (day 7) to 83.34% (day 14) (\n                      <jats:italic toggle=\"yes\">\n                        p\n                        <jats:sub>value<\/jats:sub>\n                      <\/jats:italic>\n                      \u2009&lt;\u2009.05), whereas the control group reached from 26.67% to 60%. On day 14, the intervention group experienced a 50% decrease in peri-wound erythema, while the control group only experienced a 9.5% reduction (\n                      <jats:italic toggle=\"yes\">\n                        p\n                        <jats:sub>value<\/jats:sub>\n                      <\/jats:italic>\n                      \u2009&lt;\u2009.05). Also, 3.33% of the intervention group achieved complete healing, while none in the control group did.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that 25% zinc oxide cream may function as an effective and cost-efficient alternative to conventional dressings in managing stage I and II pressure ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"10.1177_15347346251351296-img1.png\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346251351296","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:12:19Z","timestamp":1752063139000},"page":"1352-1367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-dose Topical Zinc Oxide Promotes Healing Indices of Pressure Ulcers: A Pilot Randomized Clinical Trial"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4429-9970","authenticated-orcid":false,"given":"Rayehe","family":"Fadaei","sequence":"first","affiliation":[{"name":"Hamadan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-6772","authenticated-orcid":false,"given":"Amir","family":"Larki-Harchegani","sequence":"additional","affiliation":[{"name":"Hamadan University of Medical Sciences"},{"name":"Hamadan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-6003","authenticated-orcid":false,"given":"Firozeh","family":"Sajedi","sequence":"additional","affiliation":[{"name":"Hamadan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-4619","authenticated-orcid":false,"given":"Shabnam","family":"Pourmoslemi","sequence":"additional","affiliation":[{"name":"Hamadan University of Medical Sciences"},{"name":"Hamadan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-2310","authenticated-orcid":false,"given":"Salman","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Hamadan, Shahid Fahmideh Blvd., In front of Mardom Park, Hamadan University of Medical Sciences, School of Public Health, Research Center for Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-6478","authenticated-orcid":false,"given":"Somayeh","family":"Shabib","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Pathogenesis of pressure injuries","volume":"24","author":"Milner SM","year":"2024","unstructured":"Milner SM, Mathis R. 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