{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:13Z","timestamp":1777712353526,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bingtuan Science and Technology Program","award":["2022ZD034"],"award-info":[{"award-number":["2022ZD034"]}]},{"name":"Bingtuan Science and Technology Program","award":["2023CB008-34"],"award-info":[{"award-number":["2023CB008-34"]}]},{"name":"\"Tianshan Talents\" Program for Training High-level Talents in Medicine"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Wound complications are a significant concern globally. Artificial dermal (AD) scaffolds, a novel material used in wound repair, hold promise for enhancing wound repair. However, it is limited by challenges such as prolonged vascularization time. This study aimed to investigate the effects of AD scaffold composites with recombinant human epidermal growth factor (Rh-EGF) on wound repair in rats\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rh-EGF absorption and release from the artificial dermis were evaluated using an enzyme-linked immunosorbent assay. Cell proliferation was assessed using the Cell Counting Kit-8 (CCK-8) assay. Cell adhesion was examined via electron microscopy and confocal microscopy. Rats were divided into four groups: (1) AD\/Rh-EGF composite scaffolds, (2) AD scaffolds alone, (3) Rh-EGF alone, and (4) untreated control. Wound healing was assessed over 21 days via histological analysis and wound closure rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Absorption and release experiments confirmed that the artificial dermis can retain and release Rh-EGF. In cell co-culture experiments, the Rh-EGF-combined AD scaffolds enhanced L929 cell proliferation and adhesion. The Rh-EGF composite artificial dermis promoted wound healing\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Histological and immunohistochemical analyses revealed that the Rh-EGF composite artificial dermis stimulated epithelial tissue regeneration, collagen production, cell proliferation, and angiogenesis while showing a potential trend toward reduced scar formation based on molecular markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The AD\/Rh-EGF composite scaffold accelerates wound repair while minimizing scar formation, providing a theoretical basis for its potential clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346251379705","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:53:16Z","timestamp":1759171996000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Artificial Dermal Scaffolds Compounded with Recombinant Human Epidermal Growth Factor on Wound Repair in Rats: A Comparative Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2222-1943","authenticated-orcid":false,"given":"Teng","family":"Li","sequence":"first","affiliation":[{"name":"Orthopedic Center, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunbing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopedic Center, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Yu","sequence":"additional","affiliation":[{"name":"Orthopedic Center, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-0546","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Orthopedic Center, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13832"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14447"},{"key":"e_1_3_2_4_2","first-page":"0198","article-title":"Immunomodulatory nanosystems: Advanced delivery tools for treating chronic wounds","volume":"6","author":"Chu X","year":"2023","unstructured":"Chu X, Xiong Y, Knoedler S, et al. Immunomodulatory nanosystems: Advanced delivery tools for treating chronic wounds. 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Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing. Bioact Mater. 2025 Oct;52:200-212.","journal-title":"Bioact Mater"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35996"},{"issue":"11","key":"e_1_3_2_14_2","first-page":"346","article-title":"Effect of rehabilitation intervention based on motive behavioral conversion concept on healing, self-management, and quality of life in patients with diabetic foot ulcers after artificial dermal transplantation","volume":"30","author":"Zhou M","year":"2024","unstructured":"Zhou M, Zhang X, Zhong Y, Zhang Y. Effect of rehabilitation intervention based on motive behavioral conversion concept on healing, self-management, and quality of life in patients with diabetic foot ulcers after artificial dermal transplantation. 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