{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:52:09Z","timestamp":1779299529697,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Wuhan Natural Science Foundation","award":["2025020701020266"],"award-info":[{"award-number":["2025020701020266"]}]},{"name":"Young Talent Development Program of Wuhan Fourth Hospital","award":["010"],"award-info":[{"award-number":["010"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The use of vancomycin-loaded polymethylmethacrylate cement (vPMMA) has been widely implemented in the treatment of infected diabetes-related foot ulcers (IDFUs). However, its clinical efficacy remains controversial due to limited sample sizes and significant biases in existing studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 66 patients diagnosed with IDFUs were retrospectively analyzed and assigned to four groups based on the sensitivity of the isolated pathogens to vancomycin and whether vPMMA was administered. Each group was further stratified into two subgroups according to the presence of osteomyelitis or simple soft tissue infection (STI). Clinical outcomes, including wound healing duration, number of debridement procedures, and pathogen-positive duration, were collected to evaluate the therapeutic effect of vPMMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After verifying statistical comparability using the WIfI (Wound, Ischemia, and foot Infection) classification system, the statistically significant improvement in wound healing duration was observed in the subgroup A\u2009+\u2009(with osteomyelitis caused by vancomycin-sensitive pathogens, treated with vPMMA) (69.0\u2009\u00b1\u200929.6 days, P\u2009&lt;\u20090.05). While, no significant differences were observed among the four groups (A, B, C, D) with respect to wound healing duration (71.5\u2009\u00b1\u200925.2, 93.5\u2009\u00b1\u200926.5, 91.0\u2009\u00b1\u200941.9, 97.1\u2009\u00b1\u200943.2 days, P\u2009&gt;\u20090.05), debridement numbers (P\u2009&gt;\u20090.05), or pathogen-positive duration (P\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contrary to previous reports, our findings do not support the use of vPMMA as a universally effective treatment for IDFUs. The therapy demonstrated superior efficacy compared to simple debridement only in cases where osteomyelitis was present and complete surgical clearance of the lesion was not feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346251383638","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:29Z","timestamp":1760032169000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapy with Vancomycin-Loaded Polymethylmethacrylate Cement Demonstrates Limited Advantage in the Treatment of Infected Diabetes-Related Foot Ulcers: Only Patients with Osteomyelitis Benefited"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-0547","authenticated-orcid":false,"given":"Xin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Yantai Yuhuangding Hospital, Affiliated with Qingdao University, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruokun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad429"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3687"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.10.097"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1134318"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13236"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-021-00614-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221109045"},{"key":"e_1_3_3_9_2","first-page":"9911072","article-title":"Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial","author":"Mendame Ehya RE","year":"2021","unstructured":"Mendame Ehya RE, Zhang H, Qi B, Yu A. Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial. J Diabetes Res. 2021:9911072.","journal-title":"J Diabetes Res"},{"key":"e_1_3_3_10_2","first-page":"2429136","article-title":"Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible","author":"Liu C","year":"2019","unstructured":"Liu C, You JX, Chen YX, et al. Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible. J Diabetes Res. 2019:2429136.","journal-title":"J Diabetes Res"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3648"},{"issue":"11","key":"e_1_3_3_12_2","first-page":"511","article-title":"Uber die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos [Depot effects of various antibiotics mixed with Palacos resins]","volume":"41","author":"Buchholz HW","year":"1970","unstructured":"Buchholz HW, Engelbrecht H. Uber die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos [Depot effects of various antibiotics mixed with Palacos resins]. Chirurg. 1970;41(11):511-515.","journal-title":"Chirurg"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01626"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2009.06.010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06244-w"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251383638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346251383638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251383638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:07Z","timestamp":1777457107000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346251383638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":14,"alternative-id":["10.1177\/15347346251383638"],"URL":"https:\/\/doi.org\/10.1177\/15347346251383638","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"article-number":"15347346251383638"}}