{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:09:26Z","timestamp":1791871766510,"version":"4.3.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:p>Diabetic foot ulcers (DFUs) and diabetic peripheral neuropathy (DPN) are severe complications in type 2 diabetes mellitus (T2DM). Selenium (Se) is an important element with antioxidant properties, which is crucial for human homeostasis. In this narrative mini review, we summarise the evidence on the potential association of Se with DPN and DFUs. Generally, in most of the limited number of studies, serum Se levels were significantly lower in subjects with DPN or DFUs. In addition, one study demonstrated that urinary Se levels were lower in the DPN group. Nevertheless, further investigations are needed to confirm these preliminary findings.<\/jats:p>","DOI":"10.1177\/15347346251393019","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:36:29Z","timestamp":1762191389000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diabetic Peripheral Neuropathy, Diabetic Foot Ulcers and Selenium: A mini Review"],"prefix":"10.1177","author":[{"given":"Elisavet E.","family":"Pyrgioti","sequence":"first","affiliation":[{"name":"Pharmacist, Private Practice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-7042","authenticated-orcid":false,"given":"Nikolaos D.","family":"Karakousis","sequence":"additional","affiliation":[{"name":"Democritus University of Thrace"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-634X","authenticated-orcid":false,"given":"Dimitrios S.","family":"Karagiannakis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon P.","family":"Galanakos","sequence":"additional","affiliation":[{"name":"Amarousion Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-785X","authenticated-orcid":false,"given":"Nikolaos","family":"Papanas","sequence":"additional","affiliation":[{"name":"Democritus University of Thrace"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00496-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112717"},{"key":"e_1_3_2_5_2","article-title":"Magnesium and diabetic foot ulcers: a mini review","author":"Karakousis ND","year":"2023","unstructured":"Karakousis ND, Pyrgioti EE, Georgakopoulos PN, Apergi K, Papanas N. Magnesium and diabetic foot ulcers: a mini review. Int J Low Extrem Wounds. 2023;15347346231176117, Online ahead of print.","journal-title":"Int J Low Extrem Wounds."},{"key":"e_1_3_2_6_2","article-title":"Zinc levels and diabetic foot ulcers: a mini review","author":"Karakousis ND","year":"2023","unstructured":"Karakousis ND, Pyrgioti EE, Georgakopoulos PN, Apergi K, Popovic DS, Papanas N. Zinc levels and diabetic foot ulcers: a mini review. Int J Low Extrem Wounds. 2023;15347346231214209, Online ahead of print.","journal-title":"Int J Low Extrem Wounds"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221143018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093256"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00690-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071298"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01747-x"},{"issue":"4","key":"e_1_3_2_12_2","first-page":"180","article-title":"Correlating blood selenium levels in type 2 diabetes mellitus with peripheral neuropathy and factors contributing to associated lesion development","volume":"30","author":"Xu H","year":"2024","unstructured":"Xu H, Wen Q, Ye M. Correlating blood selenium levels in type 2 diabetes mellitus with peripheral neuropathy and factors contributing to associated lesion development. 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