{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:32Z","timestamp":1777712372375,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:p>\n                    Diabetic foot ulcers (DFUs) are a serious complication of diabetes, associated with high risks of infection, amputation, and reduced quality of life. Silver nanoparticle dressings, known for their broad-spectrum antimicrobial and anti-inflammatory properties, offer a promising advanced treatment option. This prospective, randomized, single-blind controlled trial evaluated the efficacy of tetra silver tetroxide dressings compared to conventional dressings in managing DFUs, with limb salvage as the primary endpoint and wound healing parameters as secondary endpoints. Fifty-nine patients were randomly assigned to Group A (tetra silver tetroxide spray and gel, n\u2009=\u200930) or Group B (conventional dressings, n\u2009=\u200929). While no statistically significant difference in limb salvage rates was observed (Group A: 100% vs 86.21%;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.052), the silver nanoparticle dressing demonstrated superior outcomes in all secondary endpoints: a higher rate of complete healing (100% vs 82.76%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.024), reduced mean healing time (9.77 vs 18.79 weeks,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001), lower incidence of post-treatment infection (0% vs 20.69%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.011), and fewer median dressing days (62.5 vs 122.5 days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). These findings indicate that tetra silver tetroxide nanoparticle dressings significantly accelerate wound healing, reduce infection, and lessen treatment burden, supporting their use as an effective DFU treatment option.\n                  <\/jats:p>","DOI":"10.1177\/15347346251413947","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:36:38Z","timestamp":1768588598000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Silver Nanoparticles (Tetrasilver Tetroxide) in Treatment of Diabetic Foot Ulcer"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-9258","authenticated-orcid":false,"given":"Amr Abdelghaffar","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Ain Shams University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa Soliman","family":"Abdelbary","sequence":"additional","affiliation":[{"name":"Ain Shams University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abdelmonem","family":"Rizk","sequence":"additional","affiliation":[{"name":"Ain Shams University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam Abdelaziz","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Nasser Institute for Research and Treatment, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-005-0051-y"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60324-7_19"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0844"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2694"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2741\/1184"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110925"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00371"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2018.10.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano8090681"},{"key":"e_1_3_2_11_2","volume-title":"A New Fighting Chance","author":"Gordon P","year":"2014","unstructured":"Gordon P. A New Fighting Chance. 1st ed. Silver Health Institute; 2014.","edition":"1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.11.019"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201900347"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.11.979"},{"issue":"1","key":"e_1_3_2_15_2","first-page":"29","article-title":"A comparative study between conventional and nanosilver dressings in patients with diabetic ulcer","volume":"17","author":"Nancharaiah P","year":"2018","unstructured":"Nancharaiah P. A comparative study between conventional and nanosilver dressings in patients with diabetic ulcer. IOSR J Dent Med Sci. 2018;17(1):29\u201332.","journal-title":"IOSR J Dent Med Sci"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.4.306"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.1.20"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13228"},{"key":"e_1_3_2_19_2","unstructured":"International Working Group on the Diabetic Foot. IWGDF guidelines on the prevention and management of diabetic foot disease. IWGDF website. 2023. Accessed February 15 2024. https:\/\/www.iwgdfguidelines.org\/"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14345"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.18410\/jebmh\/2015\/1104"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17403"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1473"}],"container-title":["The International Journal of Lower Extremity Wounds"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251413947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15347346251413947","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15347346251413947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:05:11Z","timestamp":1777457111000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347346251413947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":22,"alternative-id":["10.1177\/15347346251413947"],"URL":"https:\/\/doi.org\/10.1177\/15347346251413947","relation":{},"ISSN":["1534-7346","1552-6941"],"issn-type":[{"value":"1534-7346","type":"print"},{"value":"1552-6941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"article-number":"15347346251413947"}}