{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:42Z","timestamp":1777712382466,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:p>The study aimed to assess the outcomes of patients with diabetic foot osteomyelitis (DFO) and concomitant soft tissue infection (STI). It is a retrospective observational study including consecutive patients affected by DFO located in the forefoot (toes and\/or rays) who referred to a specialized diabetic foot service from 2019 to 2022. Patients were categorized in two groups: those with DFO and STI and those with DFO without STI. All patients were managed by a conservative surgical approach aiming to remove only the infected bone in association with antibiotic therapy. After 1-year of follow-up, the following outcomes were evaluated and compared between groups: healing, healing time, minor amputation, major amputation, and hospitalization. Overall, 166 patients were included. The mean age was 68.5\u2009\u00b1\u200913.2 years, 94.9% of them were affected by type 2 diabetes with a mean duration of 19.3\u2009\u00b1\u20097.1 years. One hundred fourteen patients (68.7%) had DFO complicated by STI, while 52 (31.3%) had DFO without STI. The outcomes for DFO with and without STI were: healing (52.3 vs 94.2%, p\u2009=\u20090.005), healing time (7.8\u2009\u00b1\u20095.8 vs 4.6\u2009\u00b1\u20092.7 weeks, p\u2009=\u20090.0002), minor amputation (13.1 vs 3.8%, p\u2009=\u20090.04), major amputation (0 vs 0%, ns), and hospitalization (66.7 vs 48.1%, p\u2009&lt;\u20090.002) respectively. In addition, STI resulted an independent predictor of non-healing [OR 3.1, CI 95% (1.7-9.3), p\u2009=\u20090.002]. Patients with DFO complicated by STI showed higher rate of non-healing, delayed healing time, and more case of minor amputation and hospitalization in comparison to those without STI. STI was independently associated to the risk of non-healing, while any association was found for amputation and hospitalization.<\/jats:p>","DOI":"10.1177\/15347346261423281","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:41:02Z","timestamp":1771260062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Could Soft Tissue Infection Influence the Outcomes of Diabetic Foot Osteomyelitis? 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