{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:59:47Z","timestamp":1777712387228,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic foot ulcer (DFU) is a major cause of infection-related hospitalization and amputation. Negative-pressure wound therapy with instillation and dwell time (NPWTi-d) is used for complex DFU, and beraprost sodium (BS), an oral prostacyclin analogue, may improve microcirculation; evidence for their combination is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the safety and effectiveness of NPWTi-d plus BS versus NPWTi-d alone and BS with standard wound care in DFU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed hospitalized DFU patients treated from February 2019 to April 2024. Of 667 screened patients, 590 met inclusion criteria and were grouped by therapy: NPWTi-d (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009190), BS plus standard care (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009200), and NPWTi-d plus BS (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009200). Primary outcomes were 12-week healing rate, time to healing, and ulcer area reduction (ImageJ). Secondary outcomes included reinfection and DFU-related readmission at 12 weeks, 6 months, and 12 months, and quality of life (DFU-SF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12 weeks, NPWTi-d plus BS achieved faster healing than NPWTi-d alone (mean difference 2.6 days; 95% CI 0.1-5.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.042) and greater area reduction at weeks 8\u201312 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). DFU-SF improved in all groups, with consistently higher scores in the combination group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Reinfection and readmission increased over time in all groups; between-group differences were small and may reflect residual confounding. No treatment-related serious adverse events were documented. No major bleeding, symptomatic hypotension, or treatment discontinuation due to intolerance was documented during the 12-week treatment period; minor adverse events may be underreported due to the retrospective design.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort, adding oral BS to NPWTi-d was associated with faster wound closure and better DFU-related quality of life. Prospective controlled studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346261435112","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:20:06Z","timestamp":1774344006000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Beraprost Sodium Combined with Negative Pressure Drip Irrigation in the Treatment of Diabetic Foot Ulcer: A Retrospective Cohort Study"],"prefix":"10.1177","author":[{"given":"Dian","family":"Zhou","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Jiangnan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7837-507X","authenticated-orcid":false,"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangnan University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313883"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(97)01385-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.22517"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(96)00102-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970205300102"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.13-00092"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115733998229877230926073555"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.12.994"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211032046"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02405-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2023.44.20230386"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000920512.88426.90"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1165305"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017928"},{"issue":"1","key":"e_1_3_3_16_2","first-page":"639","article-title":"Prospective analysis of the efficacy of beraprost sodium combined with alprostadil on diabetic nephropathy and influence on rennin-angiotensin system and TNF-alpha","volume":"19","author":"Xu X","year":"2020","unstructured":"Xu X, Pan X, Li S. Prospective analysis of the efficacy of beraprost sodium combined with alprostadil on diabetic nephropathy and influence on rennin-angiotensin system and TNF-alpha. Exp Ther Med. 2020;19(1):639\u2013645.","journal-title":"Exp Ther Med"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2024.01.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017786"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14590"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14390"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221123638"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0118"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13956"},{"key":"e_1_3_3_24_2","volume-title":"Negative Pressure Wound Therapy","author":"Zaver V","year":"2024","unstructured":"Zaver V, Kankanalu P. 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