{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:06:57Z","timestamp":1777950417746,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. is an herbaceous annual plant belonging to the family Martyniaceae, which is widely distributed in India. Traditionally,\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruit oil has been used to treat epilepsy, sore throats, inflammatory disorders, and wound healing; however, it lacks scientific validation. This study aimed to investigate the wound-healing efficacy of\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruit oil using different\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    wound models. The oil was obtained from\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruits using traditional (Buried) techniques. Before applying these oils, an acute dermal toxicity test was performed, followed by an evaluation of wound healing efficacy in rats using incision, excision, and burn wound models. The acute dermal toxicity test indicates that\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruit oil did not cause erythema or oedema over a 7-day period. These findings confirmed the safety and non-toxicity of\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruit oil for topical use. In all wound models tested, the\n                    <jats:italic toggle=\"yes\">Martynia annua<\/jats:italic>\n                    L. fruit oil revealed (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.05) improved wound-healing activity significantly compared to the marketed povidone iodine (5% w\/w) ointment for excision and incision wounds, and silver sulfadiazine cream for burn wounds. Future research should focus on elucidating the underlying mechanisms, evaluating the therapeutic potential of Martynia annua L. fruit oil, optimizing extraction methods and product development, and exploring clinical applications.\n                  <\/jats:p>","DOI":"10.1177\/15347346261446147","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:23:26Z","timestamp":1777569806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of\n                    <i>In Vivo<\/i>\n                    Wound Healing Activity of\n                    <i>Martynia annua<\/i>\n                    L\n                    <i>.<\/i>\n                    Fruit Oil on Different Wound Models in Rats"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-0061","authenticated-orcid":false,"given":"Rameshroo","family":"Kenwat","sequence":"first","affiliation":[{"name":"Shri Rawatpura Sarkar University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0769-6202","authenticated-orcid":false,"given":"Dharmendra Prasad","family":"Kewat","sequence":"additional","affiliation":[{"name":"Shri Rawatpura Sarkar University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-9471","authenticated-orcid":false,"given":"Harish","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Shri Rawatpura Sarkar University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-3076","authenticated-orcid":false,"given":"Vijay Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Shri Rawatpura Sarkar University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-1498","authenticated-orcid":false,"given":"Veena Devi","family":"Singh","sequence":"additional","affiliation":[{"name":"Shri Rawatpura Sarkar University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-9197","authenticated-orcid":false,"given":"Pushpa Prasad","family":"Gupta","sequence":"additional","affiliation":[{"name":"Chhatrapati Shivaji institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae069"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164741"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-016-0330-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2017.06.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01858-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-023-00502-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/0113894501260002231101080505"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0506"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Calixto JB. 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