{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:01:15Z","timestamp":1784998875121,"version":"3.55.0"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Lower Extremity Wounds"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study aims to evaluate the antioxidant, antibacterial, and wound-healing properties of powders from\n                      <jats:italic toggle=\"yes\">Cytisus triflorus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Teucrium polium<\/jats:italic>\n                      , plants endemic to Algeria harvested during two phenological stages and for enhancing wound care using a rat wound model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Phytochemical characterization of powders has involved: total phenol, flavonoids and condensed tannins content, as well as the carbohydrates composition. Such investigation was supported by their efficiency as antibacterial and antioxidant determined by different test systems, namely DPPH radicals scavenging activity, reducing power and \u03b2-carotene bleaching assay. In this regard, a rat excision wound model was used to assess wound healing. Wound contraction, hydroxyproline contents and histological evaluation were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Powders from studied plants differed predominantly in their total phenol, flavonoids and condensed tannins content as well as the carbohydrates composition between phenological stages. Indeed, the powders from both plants harvested at the flowering stage showed a potential antioxidant activity and exhibited significant antibacterial activity against Gram positive bacteria. After twelve days of treatment in excision wound model, wound contractions for Cfl\u2019Ont and Tfl\u2019Ont ointments mention a value of 100% which it showed highly significant temporal reduction in those wounds area (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01) followed by Cfr\u2019Ont and Tfr\u2019Ont ointments with 98.11%, 96.88%, decreased epithelialization time, arranged derma and increased hydroxyproline content over the reference groups during the trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings have proved, for the first time, scientific evidence of the efficiency of Algerian plants namely\n                      <jats:italic toggle=\"yes\">Cytisus triflorus<\/jats:italic>\n                      L'Her and\n                      <jats:italic toggle=\"yes\">Teucrium polium<\/jats:italic>\n                      to possess a remarkable wound healing activities supporting the folkloric assertion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15347346261469616","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:42:57Z","timestamp":1784727777000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro and in Vivo Preliminary Pharmacological Evaluation of Two Algerian Plants Relevant to Accelerate Cutaneous Wound Healing in Wistar Rat's Skin"],"prefix":"10.1177","author":[{"given":"Selma","family":"Daghbouche","sequence":"first","affiliation":[{"name":"University of Blida 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-4014","authenticated-orcid":false,"given":"Dorsaf","family":"Moalla Rekik","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neila","family":"Jardak","sequence":"additional","affiliation":[{"name":"University of Sfax"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Makni","sequence":"additional","affiliation":[{"name":"University of Sfax"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slim","family":"Tounsi","sequence":"additional","affiliation":[{"name":"University of Sfax"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Rebai","sequence":"additional","affiliation":[{"name":"University of Sfax"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouheir","family":"Sahnoun","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahr-Eddine","family":"Djazouli","sequence":"additional","affiliation":[{"name":"University of Blida 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"3","key":"e_1_3_3_2_2","first-page":"718","article-title":"Evaluation of the wound healing activity of gel formulations of leaf extract of Aspila africana Fam. 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