{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:19:56Z","timestamp":1777695596813,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    This study was designed to investigate the anticancer activity of extracts of the phytomedicine DAS-77. The sulforhodamine B (SRB) in vitro cytotoxicity assay, Sarcoma-180 (S-180) ascites and solid tumor, and L1210 lymphoid leukemia in vivo models were employed. DAS-A001 (ethanol extract, IC\n                    <jats:sub>50<\/jats:sub>\n                    12 and 13 \u00b5g\/mL with HCT-116 and PC3, respectively); DAS-A002 (hydroethanol extract, IC\n                    <jats:sub>50<\/jats:sub>\n                    &lt;5 and 13 \u00b5g\/mL with HCT-116 and PC3, respectively); DAS-A003 (aqueous extract, IC\n                    <jats:sub>50<\/jats:sub>\n                    &lt;5 \u00b5g\/mL with THP-1); and DAS-A004 (dichloromethane:methanol extract; IC\n                    <jats:sub>50<\/jats:sub>\n                    &lt;5 and 17 \u00b5g\/mL with HCT-116 and PC3, respectively) demonstrated significant activity in vitro. DAS-A002 and DAS-A003 (80-120 mg\/kg) elicited significant ( P &lt; .05-.001) dose-dependent inhibition of tumor growth in the S-180 ascites model. Peak effects were produced at the highest dose of 120 mg\/kg with inhibition values of 87.50% and 89.23% for DAS-A002 and DAS-A003, respectively, compared with a value of 97.27% for 5-FU (20 mg\/kg). As regards the S-180 solid tumor model, inhibition of tumor growth was found to be 52.56% and 37.95%, respectively, for DAS-A002 and DAS-A003. The effect of DAS-A002 was comparable and not significantly different ( P &gt; .05) from that of 5-FU (20 mg\/kg; 50.18% inhibition). DAS-A003 but not DAS-A002 showed significant activity in the leukemia model with 177.78% increase in mean survival time relative to 211.11% for 5-FU. Findings in this study suggest that the hydroethanol and aqueous extracts of DAS-77 possess significant anticancer activity.\n                  <\/jats:p>","DOI":"10.1177\/1534735414555807","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:56:56Z","timestamp":1414544216000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anticancer Activity of the Phytomedicine DAS-77"],"prefix":"10.1177","volume":"14","author":[{"given":"Abidemi J.","family":"Akindele","sequence":"first","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"},{"name":"Natural Products Chemistry Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"},{"name":"Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahoor A.","family":"Wani","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh K.","family":"Satti","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo O.","family":"Adeyemi","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip M.","family":"Mondhe","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Council of Scientific & Industrial Research, Jammu-Tawi, Jammu & Kashmir, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"bibr1-1534735414555807","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.10.017"},{"key":"bibr2-1534735414555807","first-page":"386","volume":"11","author":"Park SU","year":"2012","journal-title":"EXCLI 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