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There is a pressing need, therefore, to develop and test novel drugs. Natural products including plants, microorganisms, and halobios provide rich resources for discovery of anticancer drugs. In this article, we demonstrate that emodin inhibited the growth of K562 cells harboring BCR-ABL in vitro and in vivo, and induced abundant apoptosis, which was correlated with the inhibition of PETN\/PI3K\/Akt level and deletion of BCR-ABL. These findings suggest that emodin is a promising agent to kill K562 cells harboring BCR-ABL.<\/jats:p>","DOI":"10.1177\/1534735416664784","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T22:18:43Z","timestamp":1475533123000},"page":"526-539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Emodin Exerts an Antiapoptotic Effect on Human Chronic Myelocytic Leukemia K562 Cell Lines by Targeting the PTEN\/PI3K-AKT Signaling Pathway and Deleting BCR-ABL"],"prefix":"10.1177","volume":"16","author":[{"given":"Chun-Guang","family":"Wang","sequence":"first","affiliation":[{"name":"Yongchuan Hospital, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Chongqing Medical University, Chongqing, People\u2019s Republic of 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