{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:24:21Z","timestamp":1777695861849,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Background: Treatment of chemotherapy-induced peripheral neuropathy (CIPN), which affects approximately 30% to 40% of patients treated with neuropathy-causing agents, is mainly symptomatic. Currently available interventions are of little benefit. Study Design: This study was conducted as a retrospective analysis of the efficacy of acupuncture and reflexology in alleviating CIPN in breast cancer patients. Methods: Medical records of 30 consecutive breast cancer patients who received both chemotherapy and treatment for CIPN according to our Acupuncture and Reflexology Treatment for Neuropathy (ART-N) protocol between 2011 and 2012 were reviewed. Symptom severity was rated at baseline, during, and after treatment. Results: The records of 30 breast cancer patients who had been concomitantly treated with chemotherapy and ART-N for CIPN were retrieved. Two records were incomplete, leaving a total of 28 patients who were enrolled into the study. Twenty patients (71%) had sensory neuropathy, 7 (25%) had motor neuropathy, and 1 (4%) had both sensory and motor neuropathy. Only 2 (10%) of the 20 patients with grades 1 to 2 neuropathy still reported symptoms at 12 months since starting the ART-N protocol. All 8 patients who presented with grades 3 to 4 neuropathy were symptom-free at the 12-month evaluation. Overall, 26 patients (93%) had complete resolution of CIPN symptoms. Conclusion: The results of this study demonstrated that a joint protocol of acupuncture and reflexology has a potential to improve symptoms of CIPN in breast cancer patients. The protocol should be validated on a larger cohort with a control group. It also warrants testing as a preventive intervention.<\/jats:p>","DOI":"10.1177\/1534735417690254","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T06:26:03Z","timestamp":1486016763000},"page":"258-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Acupuncture and Reflexology for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer"],"prefix":"10.1177","volume":"16","author":[{"given":"Idan","family":"Ben-Horin","sequence":"first","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peretz","family":"Kahan","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Ryvo","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Inbar","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahar","family":"Lev-Ari","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravit","family":"Geva","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"bibr1-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.0543"},{"key":"bibr2-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007853"},{"key":"bibr3-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds329"},{"key":"bibr4-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2008.00156.x"},{"key":"bibr5-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000043691.53710.53"},{"key":"bibr6-1534735417690254","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0078"},{"key":"bibr7-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn100"},{"key":"bibr8-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.160"},{"key":"bibr9-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos203"},{"key":"bibr10-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi110"},{"key":"bibr11-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002285.pub2"},{"key":"bibr12-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.102"},{"key":"bibr13-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409360666"},{"key":"bibr14-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed.2011.010025"},{"key":"bibr15-1534735417690254","first-page":"920807","volume":"2011","author":"Bao T","year":"2011","journal-title":"Pain Res Treat"},{"key":"bibr16-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000181"},{"key":"bibr17-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1231-8"},{"key":"bibr18-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/319734"},{"key":"bibr19-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"bibr20-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1136\/aim.24.2.87"},{"key":"bibr21-1534735417690254","first-page":"457","volume":"30","author":"Xu WR","year":"2010","journal-title":"Zhongguo Zhen Jiu"},{"key":"bibr22-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2011-010034"},{"key":"bibr23-1534735417690254","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0119"},{"key":"bibr24-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2813"},{"key":"bibr25-1534735417690254","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.02.018"}],"container-title":["Integrative Cancer Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735417690254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534735417690254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735417690254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:18:40Z","timestamp":1777454320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534735417690254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/1534735417690254"],"URL":"https:\/\/doi.org\/10.1177\/1534735417690254","relation":{},"ISSN":["1534-7354","1552-695X"],"issn-type":[{"value":"1534-7354","type":"print"},{"value":"1552-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}