{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:27:03Z","timestamp":1777696023620,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>In most cancer patients, chemotherapy-induced oral mucositis (OM) is a frequent side effect, leading to low quality of life and delay in therapy. The aim of this study was to evaluate the effects of Onchung-eum, a well-known herbal prescription in traditional medicine comprising 8 herbs that has long been used for skin diseases, on 5-fluorouracil (5-FU)\u2013induced OM in human pharyngeal cells and golden Syrian hamsters. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and reactive oxygen species production were measured in vitro. The effects of Onchung-eum on OM of hamster cheek pouches induced by 5-FU were evaluated histologically and using TUNEL assay. In addition, the expression of nuclear factor-\u03baB, caspase-3, and pro-inflammatory cytokines were measured by immunoblotting and immunohistochemistry. Significantly increased cell viability was observed in the Onchung-eum\u2013treated groups compared with the 5-FU\u2013treated control group. In 500 and 1000 mg\/kg Onchung-eum\u2013treated groups, the damaged epithelial layers in the cheek pouches of hamsters were significantly recovered. Moreover, at all concentrations, cell death in the cheek pouches of hamsters in the Onchung-eum\u2013treated groups significantly decreased. The expression of pro-inflammatory cytokines, nuclear factor-\u03baB, and caspase-3 also significantly decreased in Onchung-eum\u2013treated groups at 500 and 1000 mg\/kg. In conclusion, this study revealed that Onchung-eum can be used to treat chemotherapy-induced OM. However, further studies are required to understand the underlying mechanisms.<\/jats:p>","DOI":"10.1177\/1534735418805560","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:21:29Z","timestamp":1539044489000},"page":"1285-1296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of\n                    <i>Onchung-eum<\/i>\n                    , an Herbal Prescription, on 5-Fluorouracil\u2013Induced Oral Mucositis"],"prefix":"10.1177","volume":"17","author":[{"given":"Jae-Woo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 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