{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:12:54Z","timestamp":1777695174968,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Traditional Korean Medicine R&D program funded by the Republic of Korea Ministry of Health and Welfare through the Korea Health Industry Development Institute","award":["HB16C0067"],"award-info":[{"award-number":["HB16C0067"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Integr Cancer Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Korean herbal medicine treatment (KHMT) involves treating with a combination of natural products, which have been used for thousands of years. Recently, it has been reported to be effective and safe in cancer patients. This case report demonstrates the efficacy of KHMT in a 49-year-old man with malignant pleural mesothelioma (MPM), a rare and highly aggressive cancer. The patient showed recurrent pleural effusion and was diagnosed with epithelioid MPM at cT3NxM0 stage III in December 2017. The multidisciplinary care team recommended multimodal treatment based on an extrapleural pneumonectomy, but he refused this because the treatment was aggressive and the effectiveness was unclear. He decided to undergo pemetrexed plus cisplatin chemotherapy if his condition worsened. He visited the Korean Medicine Cancer Center for alternative treatment options. A KHMT regimen, consisting of twice-daily Gunchil-dan and thrice-daily Bangam-tang, was initiated in December 2017. Since commencement of KHMT, computed tomography and X-ray imaging scans have shown no significant interval changes and progression. At 21 months into treatment (September 2019), no significant adverse events have occurred. Given that the median overall survival of patients with MPM is approximately 1 year, the ongoing progression-free survival of this patient for 21 months is relatively long. This case, therefore, suggests that KHMT is a potential treatment option for MPM patients.<\/jats:p>","DOI":"10.1177\/1534735420908345","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T06:25:37Z","timestamp":1582698337000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prolonged Progression-Free Survival in a Patient With Malignant Pleural Mesothelioma Following Korean Herbal Medicine Treatment Alone: A Case Report"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-215X","authenticated-orcid":false,"given":"Sung Soo","family":"Yoon","sequence":"first","affiliation":[{"name":"Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-1915","authenticated-orcid":false,"given":"Jee Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Woo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"bibr1-1534735420908345","unstructured":"American Cancer Society. Cancer facts & figures 2017: special section\u2014rare cancers in adults. https:\/\/tinyurl.com\/yb4joe3c. Accessed September 10, 2019."},{"key":"bibr2-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"bibr3-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.02.129"},{"key":"bibr4-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1177\/1534735413510023"},{"key":"bibr5-1534735420908345","unstructured":"US Department of Health and Human Services; National Institutes of Health; National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf. Published November 27, 2017. Accessed September 10, 2019."},{"key":"bibr6-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"bibr7-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-22"},{"key":"bibr8-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039510"},{"key":"bibr9-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3943"},{"key":"bibr10-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx427"},{"key":"bibr11-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70149-8"},{"key":"bibr12-1534735420908345","unstructured":"National Comprehensive Cancer Network. Malignant pleural mesothelioma, Version 2, 2019. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpm.pdf. Accessed September 10, 2019."},{"key":"bibr13-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01238-6"},{"key":"bibr14-1534735420908345","volume-title":"Compendium of Prescriptions From the Countryside (Hyangyakjipseongbang)","volume":"1433","author":"Yoo HT"},{"key":"bibr15-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409336438"},{"key":"bibr16-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0237"},{"key":"bibr17-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2017.10.013"},{"key":"bibr18-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/203168"},{"key":"bibr19-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409359772"},{"key":"bibr20-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq154"},{"key":"bibr21-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1159\/000334695"},{"key":"bibr22-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500523"},{"key":"bibr23-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1159\/000327306"},{"key":"bibr24-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2009.04.001"},{"key":"bibr25-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/874276"},{"key":"bibr26-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409359180"},{"key":"bibr27-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.894093"},{"key":"bibr28-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.08.010"},{"key":"bibr29-1534735420908345","first-page":"189","volume":"23","author":"Auyeung KK","year":"2009","journal-title":"Int J Mol Med"},{"key":"bibr30-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24397"},{"key":"bibr31-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl238"},{"key":"bibr32-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.10.1.87"},{"key":"bibr33-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250186"},{"key":"bibr34-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-315LE"},{"key":"bibr35-1534735420908345","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01315.x"},{"key":"bibr36-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1007\/BF02488883"},{"key":"bibr37-1534735420908345","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.04.026"}],"container-title":["Integrative Cancer Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735420908345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1534735420908345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1534735420908345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:16:48Z","timestamp":1777454208000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1534735420908345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"alternative-id":["10.1177\/1534735420908345"],"URL":"https:\/\/doi.org\/10.1177\/1534735420908345","relation":{},"ISSN":["1534-7354","1552-695X"],"issn-type":[{"value":"1534-7354","type":"print"},{"value":"1552-695X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1534735420908345"}}